Department of Otolaryngology Head and Neck Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Department of Gastrointestinal Endoscopy, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Scand J Gastroenterol. 2022 Dec;57(12):1430-1434. doi: 10.1080/00365521.2022.2094721. Epub 2022 Jul 15.
There are a few articles to study the relationship between bile reflux gastritis (BRG) and infection, and the results are debatable. This study set out to determine the relationship between BRG and () infection.
In this retrospective study, patients from January, 1st 2013 to January, 1st, 2021 were divided into two groups based on whether they had BRG. The control group was got by 1:1 propensity-score matching (PSM) based on age and sex. Then, the relationship between BRG and H. pylori in patients was analyzed Chi-squared test and Phi (φ) detection.
26449 patients were included in this study, and there were 1918 patients in each group after age and sex matching. patients with HP were responsible for 35% (9345/26449) and patients with BRG were 7% (1918/26449). Further relationship exploration, there is a negative, but weak, the relationship between BRG and HP infection ( = 45.62, < .001, Phi (φ)= -0.109).
Patients with bile reflux may have less likely to get HP infection. HP eradication is an important thing for the prevention of gastric cancer and this study serves as a foundation and may provide directions for future research.
有一些文章研究了胆汁反流性胃炎（BRG）与感染之间的关系，结果存在争议。本研究旨在确定 BRG 与（）感染之间的关系。
在这项回顾性研究中，根据是否患有 BRG 将 2013 年 1 月 1 日至 2021 年 1 月 1 日的患者分为两组。对照组通过年龄和性别 1:1 倾向评分匹配（PSM）获得。然后，分析 BRG 与患者幽门螺杆菌（H. pylori）之间的关系，采用卡方检验和 Phi（φ）检测。
本研究共纳入 26449 例患者，年龄和性别匹配后每组各有 1918 例患者。HP 阳性患者占 35%（9345/26449），BRG 患者占 7%（1918/26449）。进一步的关系探索表明，BRG 与 HP 感染之间存在负相关关系，但较弱（=45.62，<0.001，Phi（φ）=-0.109）。
胆汁反流患者可能不太容易感染 HP。根除 HP 是预防胃癌的重要措施，本研究为未来的研究提供了基础，并可能为未来的研究提供方向。
