调查 2021 年世卫组织宫颈癌筛查协议在筛查不足人群中应用的可行性：预防和筛查创新项目以消除宫颈癌（PRESCRIP-TEC）。
Investigating feasibility of 2021 WHO protocol for cervical cancer screening in underscreened populations: PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC).
机构信息
Department of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Department of Economics, Econometrics and Finance, Faculty of Economics and Business, University of Groningen, Groningen, Netherlands.
出版信息
BMC Public Health. 2022 Jul 15;22(1):1356. doi: 10.1186/s12889-022-13488-z.
BACKGROUND
High-risk human papillomavirus (hrHPV) testing has been recommended by the World Health Organization as the primary screening test in cervical screening programs. The option of self-sampling for this screening method can potentially increase women's participation. Designing screening programs to implement this method among underscreened populations will require contextualized evidence.
METHODS
PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC) will use a multi-method approach to investigate the feasibility of implementing a cervical cancer screening strategy with hrHPV self-testing as the primary screening test in Bangladesh, India, Slovak Republic and Uganda. The primary outcomes of study include uptake and coverage of the screening program and adherence to follow-up. These outcomes will be evaluated through a pre-post quasi-experimental study design. Secondary objectives of the study include the analysis of client-related factors and health system factors related to cervical cancer screening, a validation study of an artificial intelligence decision support system and an economic evaluation of the screening strategy.
DISCUSSION
PRESCRIP-TEC aims to provide evidence regarding hrHPV self-testing and the World Health Organization's recommendations for cervical cancer screening in a variety of settings, targeting vulnerable groups. The main quantitative findings of the project related to the impact on uptake and coverage of screening will be complemented by qualitative analyses of various determinants of successful implementation of screening. The study will also provide decision-makers with insights into economic aspects of implementing hrHPV self-testing, as well as evaluate the feasibility of using artificial intelligence for task-shifting in visual inspection with acetic acid.
TRIAL REGISTRATION
ClinicalTrials.gov, NCT05234112 . Registered 10 February 2022.
背景
世界卫生组织建议将高危型人乳头瘤病毒（hrHPV）检测作为宫颈筛查项目中的主要筛查检测方法。这种筛查方法的自我采样选择可能会增加女性的参与度。为了在未充分筛查的人群中实施这种方法，需要制定有针对性的筛查计划，这需要基于具体情况的证据。
方法
预防和筛查创新项目（PRESCRIP-TEC）将采用多方法的方法，研究在孟加拉国、印度、斯洛伐克共和国和乌干达实施一种以 hrHPV 自我检测为主要筛查检测方法的宫颈癌筛查策略的可行性。研究的主要结果包括筛查计划的参与率和覆盖率以及对后续随访的依从性。这些结果将通过前后准实验设计进行评估。研究的次要目标包括分析与客户相关的因素和与宫颈癌筛查相关的卫生系统因素、对人工智能决策支持系统的验证研究以及对筛查策略的经济评估。
讨论
PRESCRIP-TEC 旨在为各种环境中的 hrHPV 自我检测和世界卫生组织的宫颈癌筛查建议提供证据，针对弱势群体。该项目与筛查参与率和覆盖率相关的主要定量研究结果将辅以对成功实施筛查的各种决定因素的定性分析。该研究还将为决策者提供有关实施 hrHPV 自我检测的经济方面的见解，以及评估在醋酸视觉检查中使用人工智能进行任务转移的可行性。
试验注册
ClinicalTrials.gov，NCT05234112。于 2022 年 2 月 10 日注册。
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