Department of Oral Health, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.
Department of Dentistry and Oral Surgery, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.
BMC Oral Health. 2022 Jul 15;22(1):287. doi: 10.1186/s12903-022-02325-9.
Increased bacterial presence in the tongue coating and thereby, the saliva, may be a risk factor for postoperative complications such as surgical site infection or postoperative pneumonia after cancer surgery. However, no method for cleaning tongue coating has been established experimentally. The purpose of this study was to verify the effect of brushing with 3% hydrogen peroxide on suppression of the number of bacteria in tongue coating.
Sixteen patients with gastric cancer or colorectal cancer undergoing surgery were randomly allocated to control and intervention groups. In the control group, the tongue was brushed for 30 s with a water-moistened toothbrush, while in the intervention group, the tongue was brushed for 30 s with a toothbrush moistened with 3% hydrogen peroxide. Bacterial counts on tongue coating were measured before and 30 s after cleaning the tongue coating using the Rapid Oral Bacteria Quantification System.
In the control group, the number of bacteria on the tongue did not decrease significantly after tongue cleaning on the day before surgery, but did on the day after surgery. In contrast, in the intervention group, the number of bacteria on the tongue decreased significantly after tongue cleaning both on the day before and the day after surgery. Furthermore, when comparing the control and intervention groups, the intervention group had a greater reduction effect.
Tongue brushing with 3% hydrogen peroxide is a useful method to reduce the number of bacteria on the tongue in patients with gastrointestinal cancer undergoing surgery. Trial registration jRCTs071200020 (July 3, 2020).
舌黏膜及唾液中细菌数量的增加可能是癌症术后并发症（如手术部位感染或术后肺炎）的一个风险因素。然而，目前尚无有效的舌黏膜清洁方法。本研究旨在验证使用 3%双氧水刷牙对抑制舌黏膜细菌数量的效果。
将 16 例接受胃癌或结直肠癌手术的患者随机分为对照组和干预组。对照组采用清水湿润的牙刷刷牙 30s，干预组采用 3%双氧水湿润的牙刷刷牙 30s。使用 Rapid Oral Bacteria Quantification System 分别在术前及刷牙后 30s 测量舌黏膜细菌数量。
对照组患者术前舌黏膜细菌数量在刷牙后无明显减少，但术后有减少；而干预组患者术前、术后舌黏膜细菌数量均有明显减少，与对照组相比，干预组的减少效果更显著。
对于接受胃肠癌手术的患者，使用 3%双氧水刷牙是一种有效减少舌黏膜细菌数量的方法。
jRCTs071200020（2020 年 7 月 3 日）。
