Barbucci R, Baszkin A, Benvenuti M, de Lourdes Costa M, Ferruti P
J Biomed Mater Res. 1987 Apr;21(4):443-57. doi: 10.1002/jbm.820210405.
Poly(amido-amine) chains grafted onto polyurethanes and glass form stable complexes with heparin yielding potential nonthrombogenic surfaces. The characterization of the surfaces, and the product of each chemical reaction including final heparinized surfaces, has been studied by contact angle data and scanning electron microscopy (SEM). Air in water, octane in water, and drop-on-plate contact angle data were used to estimate surface (gamma sv) and interfacial (gamma sw) free energies. Solid-water work of adhesion (Wa) and its dispersive (Wda) and polar (Ipsw) components were calculated for all studied surfaces. It has been found that the viscosity of polyurethane solution used for film casting influences wetting properties of these films. It has also been found that a direct correlation exists between the Ipsw/Wda values and the degree of coverage of the surfaces by cellular deposits after their exposure to platelet-rich plasma. Final heparinized polyurethane and glass materials are hydrophilic, their Ipsw/Wda ratio is high, and little or no cellular deposit is observed on their surfaces.
接枝到聚氨酯和玻璃上的聚（酰胺 - 胺）链与肝素形成稳定的复合物，产生潜在的抗血栓表面。已通过接触角数据和扫描电子显微镜（SEM）研究了这些表面以及包括最终肝素化表面在内的每种化学反应产物的表征。使用空气中水、辛烷中水滴在平板上的接触角数据来估计表面（γsv）和界面（γsw）自由能。计算了所有研究表面的固 - 水粘附功（Wa）及其分散（Wda）和极性（Ipsw）分量。已发现用于流延成膜的聚氨酯溶液的粘度会影响这些膜的润湿性。还发现Ipsw / Wda值与富血小板血浆暴露后细胞沉积物在表面的覆盖程度之间存在直接相关性。最终的肝素化聚氨酯和玻璃材料具有亲水性，其Ipsw / Wda比值较高，并且在其表面上几乎没有观察到细胞沉积物。
