Saito S, Inoue A, Ono K
J Bone Joint Surg Br. 1987 May;69(3):346-51. doi: 10.1302/0301-620X.69B3.3584182.
We have studied core biopsy specimens from 16 femoral heads affected by idiopathic avascular necrosis at the silent stage, when there were no clinical or radiographic manifestations but scintigraphy was positive. All the specimens showed necrosis of trabeculae and of bone marrow, but the most common and characteristic feature was evidence of old and new haemorrhage in the marrow. In the areas of intramedullary haemorrhages, trabeculae and bone marrow were completely necrotic, with a transitional area of incomplete necrosis between these areas and those without haemorrhagic lesions, where the trabeculae and bone marrow were normal. There was good correlation between necrosis and haemorrhagic episodes, and it was concluded that repeated intramedullary haemorrhage at the silent stage is probably related to the pathogenesis of idiopathic avascular necrosis of the femoral head.
我们研究了16例处于静止期的特发性股骨头缺血性坏死的股骨头的核心活检标本，此时尚无临床或影像学表现，但骨闪烁显像呈阳性。所有标本均显示小梁和骨髓坏死，但最常见和特征性的表现是骨髓中有新旧出血的证据。在髓内出血区域，小梁和骨髓完全坏死，在这些区域与无出血性病变的区域之间存在不完全坏死的过渡区，那里的小梁和骨髓是正常的。坏死与出血发作之间存在良好的相关性，得出的结论是，静止期反复的髓内出血可能与股骨头特发性缺血性坏死的发病机制有关。
