Prashar Yash, Patel Nilesh J
Ganpat University, Ganpat Vidyanagar, Mehsana-Gozaria Highway, Kherva, Gujarat 384012, India.
Department of Pharmacology, Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar, Mehsana-Gozaria Highway, Kherva, Gujarat 384012, India.
J Ayurveda Integr Med. 2023 Mar-Apr;14(2):100582. doi: 10.1016/j.jaim.2022.100582. Epub 2022 Jul 13.
Myrica nagi is popular in unani and ayurveda. Chemical constituents like myricetin isolated from its fruit has been shown to exert beneficial effects against cardiovascular disease, cancer, inflammatory conditions, and metabolic disorders.
This study aimed to elucidate the anti-obesity effect of the methanolic extract of M. nagi (MEMN) using in vivo animal models of obesity induced by gold thioglucose or a high-fat diet.
The obese mice were treated or untreated with MEMN for 8 weeks. Thereafter, feed intake, Lee index, and body mass index (BMI); biochemical parameters such as lipid profile, liver enzymes and specific biomarkers of obesity, including insulin, leptin, adiponectin, free fatty acids (FFA), monocyte chemoattractant protein (MCP)-1, and resistin, were recorded. The weight and histopathology of organs and fat tissue were examined to validate the effectiveness of the extract.
MEMN administration at various doses significantly reduced the induced weight gain, feed intake, BMI, and Lee index. Adipose tissue decreased as the MEMN dose increased. MEMN attenuated liver enzyme activity, decreased lipid, leptin, MCP-1, resistin, and FFA levels, and increased adiponectin levels. It also increased protection of liver cells and decreased accumulation of mesenteric fat.
MEMN supplementation decreased weight and improved obesity serum/plasma lipid biomarker, insulin, leptin, adiponectin, MCP-1, and resistin levels. The weight-reducing activity of MEMN may be mediated by decreased gastrointestinal fat absorption and modulation of inflammation associated signaling pathways, leading to reduced adipose inflammation associated with energy expenditure.
杨梅在尤那尼医学和阿育吠陀医学中颇受关注。从其果实中分离出的杨梅素等化学成分已显示出对心血管疾病、癌症、炎症性疾病和代谢紊乱具有有益作用。
本研究旨在使用硫代葡萄糖金或高脂饮食诱导的肥胖体内动物模型，阐明杨梅甲醇提取物（MEMN）的抗肥胖作用。
肥胖小鼠接受或不接受MEMN治疗8周。此后，记录食物摄入量、李氏指数和体重指数（BMI）；记录生化参数，如血脂谱、肝酶以及肥胖的特定生物标志物，包括胰岛素、瘦素、脂联素、游离脂肪酸（FFA）、单核细胞趋化蛋白（MCP）-1和抵抗素。检查器官和脂肪组织的重量及组织病理学，以验证提取物的有效性。
不同剂量的MEMN给药显著降低了诱导的体重增加、食物摄入量、BMI和李氏指数。随着MEMN剂量增加，脂肪组织减少。MEMN减弱了肝酶活性，降低了脂质、瘦素、MCP-1、抵抗素和FFA水平，并提高了脂联素水平。它还增强了对肝细胞的保护并减少了肠系膜脂肪的积累。
补充MEMN可减轻体重，并改善肥胖血清/血浆脂质生物标志物、胰岛素、瘦素、脂联素、MCP-1和抵抗素水平。MEMN的减肥活性可能是通过减少胃肠道脂肪吸收和调节炎症相关信号通路来介导的，从而导致与能量消耗相关的脂肪炎症减少。
