Alim Md Abdul, Mumu Tarana Jannat, Tamanna Ummay Salma, Khan Md Moin, Miah Md Imran, Islam Md Shahikul, Jesmin Zannat Ara, Khan Tayeba, Hasan Md Rakibul, Alam Md Jahangir, Murtaja Reza Linkon Khan Md, Rahman Md Nannur, Begum Rokeya, Prodhan Utpal Kumar
Department of Food Technology and Nutritional Science, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail, 1902, Bangladesh.
Ahsania Mission Cancer and General Hospital, Dhaka, 1230, Bangladesh.
Heliyon. 2024 Feb 10;10(4):e25880. doi: 10.1016/j.heliyon.2024.e25880. eCollection 2024 Feb 29.
The current study assessed the hypolipidemic effect and modulation of hepatic enzymes by different edible oils in obese Wistar rats. In order to conduct this study, 36 Wistar rats that were collected at 5 weeks of age and weighed an average of 70 g were split into two groups: 28 of them were fed a high-fat diet (HFD) and 8 of them were fed a control diet. After 5 weeks of feeding, rats from the HFD (obese, n = 4) and the control diet group (n = 4) were sacrificed. Subsequently, the rest of obese rats (n = 24) were separated into six groups, including the continuing high-fat (CHF) diet group, rice bran oil (RBO) diet group, olive oil (OO) diet group, soybean oil (SO) diet group, cod liver oil (CLO) diet group, and sunflower oil (SFO) diet group, and the continuing control diet group (n = 4). Rats from each group were sacrificed following an additional 5 weeks, and all analytical tests were carried out. The results found that the interventions of RBO, CLO, and SFO in obese rats reduced their body weight non-significantly when compared with CHF. It was also observed that a non-significant reduction in weight of the heart, AAT, and EAT occurred by RBO, OO, SO, and CLO, while SFO reduced the AAT level significantly (p < 0.05). Besides, RBO, OO, SO, CLO, and SFO decreased IBAT and liver fat significantly compared to CHF. Similarly, the administration of RBO, OO, SO, and CLO reduced ALT significantly. RBO reduced GGT (p < 0.05) significantly, but other oils did not. The given oil has the efficiency to reduce TC, TAG, and LDL-C but increase HDL-C significantly. These findings suggest that different edible oils can ameliorate obesity, regulate lipid profiles, and modulate hepatic enzymes.
本研究评估了不同食用油对肥胖Wistar大鼠的降血脂作用及对肝酶的调节作用。为开展本研究，收集了36只5周龄、平均体重70克的Wistar大鼠，将其分为两组：其中28只喂食高脂饮食（HFD），8只喂食对照饮食。喂食5周后，处死高脂饮食组（肥胖，n = 4）和对照饮食组（n = 4）的大鼠。随后，将其余肥胖大鼠（n = 24）分为六组，包括持续高脂（CHF）饮食组、米糠油（RBO）饮食组、橄榄油（OO）饮食组、大豆油（SO）饮食组、鱼肝油（CLO）饮食组和向日葵油（SFO）饮食组，以及持续对照饮食组（n = 4）。再过5周后处死每组大鼠，并进行所有分析测试。结果发现，与CHF组相比，RBO、CLO和SFO对肥胖大鼠的干预使其体重有不显著降低。还观察到，RBO、OO、SO和CLO使心脏、AAT和EAT的重量有不显著降低，而SFO显著降低了AAT水平（p < 0.05）。此外，与CHF组相比，RBO、OO、SO、CLO和SFO显著降低了IBAT和肝脏脂肪。同样，RBO、OO、SO和CLO的给药显著降低了ALT。RBO显著降低了GGT（p < 0.05），但其他油类没有。所给油类有降低TC、TAG和LDL - C但显著升高HDL - C的功效。这些发现表明，不同食用油可改善肥胖、调节血脂谱并调节肝酶。
