Theodorakopoulou Marieta P, Alexandrou Maria-Eleni, Karagiannidis Artemios G, Geladari Virginia, Polychronidou Georgia, Papagianni Aikaterini, Sarafidis Pantelis
Department of Nephrology, Hippokration Hospital, Aristotle University, Thessaloniki, Greece.
J Hum Hypertens. 2023 Jul;37(7):519-523. doi: 10.1038/s41371-022-00725-6. Epub 2022 Jul 16.
Increased blood pressure variability (BPV) is strongly associated with cardiovascular events in end-stage kidney disease patients. Male hemodialysis patients present higher cardiovascular risk compared with females. The aim of this study is to investigate sex differences in short-term BPV in hemodialysis patients. 129 male and 91 female hemodialysis patients that underwent 48-h ABPM were included in this analysis. Standard deviation (SD), weighted SD (wSD), coefficient of variation (CV), and average real variability (ARV) of SBP and DBP were calculated with validated formulas. Age, dialysis vintage and history of major comorbidities did not differ between men and women. 48-h SBP/DBP (137.2 ± 17.4/81.9 ± 12.1 mmHg vs 132.2 ± 19.2/75.9 ± 11.7 mmHg, p = 0.045/<0.001) was significantly higher in men than women. During the 48-h period, all systolic BPV indices were similar between men and women (48-h SBP-ARV: 12.0 ± 2.9 vs 12.1 ± 3.2 mmHg, p = 0.683); 48-h DBP-SD, DBP-wSD and DBP-ARV (9.1 ± 1.6 vs 8.4 ± 1.8 mmHg, p = 0.005) were higher in men. In conclusion, short-term diastolic BPV indices are higher in male than female hemodialysis patients. Increased BPV may impact on the higher incidence of cardiovascular events observed in male hemodialysis patients.
血压变异性（BPV）增加与终末期肾病患者的心血管事件密切相关。男性血液透析患者的心血管风险高于女性。本研究旨在探讨血液透析患者短期BPV的性别差异。本分析纳入了129例接受48小时动态血压监测（ABPM）的男性和91例女性血液透析患者。使用经过验证的公式计算收缩压（SBP）和舒张压（DBP）的标准差（SD）、加权标准差（wSD）、变异系数（CV）和平均实际变异性（ARV）。男性和女性在年龄、透析时间和主要合并症病史方面无差异。男性的48小时SBP/DBP（137.2±17.4/81.9±12.1mmHg vs 132.2±19.2/75.9±11.7mmHg，p = 0.045/<0.001）显著高于女性。在48小时期间，男性和女性的所有收缩压BPV指标相似（48小时SBP-ARV：12.0±2.9 vs 12.1±3.2mmHg，p = 0.683）；男性的48小时DBP-SD、DBP-wSD和DBP-ARV（9.1±1.6 vs 8.4±1.8mmHg，p = 0.005）更高。总之，男性血液透析患者的短期舒张压BPV指标高于女性。BPV增加可能影响男性血液透析患者中观察到的心脑血管事件的较高发生率。
