Chemistry Department Science and Letters Faculty, Adiyaman University, 02040, Adiyaman, Türkiye.
Bull Environ Contam Toxicol. 2022 Sep;109(3):484-487. doi: 10.1007/s00128-022-03583-7. Epub 2022 Jul 16.
The glutathione reductase (GR) of baker's yeast (Saccharomyces cerevisiae) was exposed to titanium dioxide nanoparticles (TiO NPs) and zinc oxide nanoparticles (ZnO NPs) at concentrations of 0, 25, 50, 100, 250, and 500 mg/L (ppm) in vitro. According to the calculations, the effect of 25, 50, 100, 250, and 500 mg/L TiO NPs on GR enzyme activities resulted in percentage changes of - 3.12; - 0.87; - 2.12; - 2.12, and - 1.50, respectively. Percentage changes in GR enzyme activities with the effect of 25, 50, 100, 250, and 500 mg/L ZnO NPs were calculated as - 2.01; + 1.88; + 0.38; - 2.51, and + 0.75, respectively. It can be deduced from this research that the change in concentrations of TiO NPs and ZnO NPs has no statistically significant effect on GR enzyme activities in comparison with the control groups (p > 0.05, N = 3).
将酿酒酵母（Saccharomyces cerevisiae）的谷胱甘肽还原酶（GR）暴露于浓度为 0、25、50、100、250 和 500mg/L（ppm）的二氧化钛纳米颗粒（TiO NPs）和氧化锌纳米颗粒（ZnO NPs）中进行体外实验。根据计算，25、50、100、250 和 500mg/L TiO NPs 对 GR 酶活性的影响导致酶活性的百分比变化分别为-3.12%、-0.87%、-2.12%、-2.12%和-1.50%。25、50、100、250 和 500mg/L ZnO NPs 对 GR 酶活性的影响导致酶活性的百分比变化分别计算为-2.01%、+1.88%、+0.38%、-2.51%和+0.75%。可以从这项研究中推断，与对照组相比（p＞0.05，N=3），TiO NPs 和 ZnO NPs 浓度的变化对 GR 酶活性没有统计学上的显著影响。
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