School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland.
Division of Health Services, Norwegian Institute of Public Health, Oslo, Norway.
BMC Prim Care. 2022 Jul 16;23(1):175. doi: 10.1186/s12875-022-01775-y.
Benzodiazepine receptor agonists (BZRAs) are often prescribed for long-term use. However, guidelines recommend limiting prescriptions to short-term use (< 4 weeks) to reduce the risk of adverse effects and dependence. A recent systematic review reported that brief interventions targeting long-term BZRA use in primary care (e.g., short consultations, written letters to patients) were effective in helping patients to discontinue BZRA medication. However, the complexity of these interventions has not been examined in detail. This study aimed to apply the intervention Complexity Assessment Tool for Systematic Reviews (iCAT_SR) to brief interventions targeting long-term BZRA use. METHODS: Two reviewers independently assessed the interventions using the six core iCAT_SR dimensions: organisational level/ category targeted, behaviour targeted, number of intervention components, degree of tailoring, skill level required by those delivering and receiving the intervention. The four optional iCAT_SR dimensions were applied where possible. A scoring system was using to calculate a complexity score for each intervention. Pearson's correlations were used to assess the relationship between intervention complexity and effect size, as well as the relationship between intervention complexity and number of component behaviour change techniques (BCTs). Inter-rater reliability was calculated using Cohen's Kappa coefficient.
Four of the six core iCAT_SR dimensions were applied to the interventions with high inter-rater reliability (Cohen's Kappa = 0.916). Application of the four optional dimensions was prevented by a lack of detail in study reports. Intervention complexity scores ranged from 8 to 11 (median: 11). There was no relationship detected between intervention complexity and either intervention effect size or number of component BCTs.
This study adds to the literature on worked examples of the practical application of the iCAT_SR. The findings highlight how more detailed reporting of interventions is needed in order to optimise the application of iCAT_SR and its potential to differentiate between interventions across the full range of complexity dimensions. Further work is needed to establish the validity of applying a scoring system to iCAT_SR assessments.
苯二氮䓬受体激动剂(BZRAs)常用于长期使用。然而,指南建议将处方限制在短期使用(<4 周)内,以降低不良反应和依赖的风险。最近的系统评价报告称,针对初级保健中长期 BZRA 使用的简短干预措施(例如,简短咨询、给患者的书面信件)在帮助患者停止 BZRA 药物方面是有效的。然而,这些干预措施的复杂性尚未详细检查。本研究旨在应用干预措施系统评价复杂性评估工具(iCAT_SR)来评估针对长期 BZRA 使用的简短干预措施。
两名审查员独立使用 iCAT_SR 的六个核心维度评估干预措施:针对的组织层面/类别、针对的行为、干预组件的数量、定制程度、实施和接受干预的人员所需的技能水平。在可能的情况下应用了四个可选的 iCAT_SR 维度。使用评分系统为每个干预措施计算一个复杂性得分。使用 Pearson 相关系数评估干预复杂性与效应大小之间的关系,以及干预复杂性与行为改变技术(BCT)组件数量之间的关系。使用 Cohen's Kappa 系数计算组内可靠性。
六个核心 iCAT_SR 维度中的四个维度被应用于干预措施,具有较高的组内可靠性(Cohen's Kappa=0.916)。由于研究报告缺乏细节,无法应用四个可选维度。干预复杂性得分范围为 8 至 11(中位数:11)。未检测到干预复杂性与干预效果大小或组件 BCT 数量之间的关系。
本研究增加了关于 iCAT_SR 实际应用的实例研究的文献。研究结果强调了需要更详细地报告干预措施,以便优化 iCAT_SR 的应用及其在整个复杂性维度范围内区分干预措施的潜力。需要进一步工作来确定应用评分系统对 iCAT_SR 评估的有效性。