Department of Respiratory and Critical Care Medicine, Fujian Province, the First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong road, Taijiang district, Fuzhou, 350005, People's Republic of China.
Fujian Provincial Sleep-Disordered Breathing Clinic Center, Fujian, China.
BMC Musculoskelet Disord. 2022 Jul 16;23(1):682. doi: 10.1186/s12891-022-05644-8.
Hypoxia in obstructive sleep apnea (OSA) patients during sleep may have an effect on bone metabolism. Few data regarding evaluation of bone metabolism in young individuals diagnosed with OSA. In this study, we aim to identify the association between bone mineral density and OSA in young men (≤ 40 years old of age).
Consecutive male subjects who underwent polysomnography were enrolled. Serum calcium, 25-hydroxyvitamin-D3, β-isomerized form C-terminal telopeptide of type I collagen, osteocalcin and procollagen type 1 N-propeptide were measured in all participants, and bone mineral density (BMD) at lumbar spine (L1-L4), femoral neck and hip total were determined by dual energy X-ray absorption (DXA).
The population consisted of 85 subjects (mean age 35.53 years). The BMD at lumbar spine (L1-L4) in moderate OSA patients was higher than control and severe OSA group significantly (p = 0.036). After adjustment for confounding factors, stepwise multiple linear regression analyses showed LaSO (β = 0.340, p = 0.008) as an independent explanatory variable for Lumbar L1-L4 BMD, LaSO (β = 0.304, p = 0.037), BMI (β = 0.393, p = 0.008) for femur neck BMD and BMI (β = 0.720, p = 0.002) for hip total BMD.
Our finding indicated that there was a relationship between OSA and bone metabolism in younger men, and moderate OSA-related hypoxia positively related with BMD. This study also showed that different degrees of recurrent hypoxia had different effects on bone metabolism, a finding that required further investigation.
阻塞性睡眠呼吸暂停（OSA）患者睡眠中的缺氧可能对骨代谢产生影响。关于年轻 OSA 患者骨代谢评估的数据较少。本研究旨在确定年轻男性（≤40 岁）骨密度与 OSA 之间的关系。
连续入组行多导睡眠图检查的男性患者。所有参与者均测量血清钙、25-羟维生素 D3、I 型胶原β-异构化 C 端肽、骨钙素和前胶原 1 N-端前肽，并通过双能 X 线吸收（DXA）测定腰椎（L1-L4）、股骨颈和髋部总骨密度。
该人群由 85 例患者（平均年龄 35.53 岁）组成。中重度 OSA 患者腰椎（L1-L4）骨密度高于对照组和重度 OSA 组（p=0.036）。在调整混杂因素后，逐步多元线性回归分析显示，最低血氧饱和度（LaSO）（β=0.340，p=0.008）是腰椎 L1-L4 骨密度的独立解释变量，LaSO（β=0.304，p=0.037）、BMI（β=0.393，p=0.008）是股骨颈骨密度的独立解释变量，BMI（β=0.720，p=0.002）是髋部总骨密度的独立解释变量。
我们的发现表明，年轻男性的 OSA 与骨代谢之间存在关系，中重度 OSA 相关的缺氧与骨密度呈正相关。本研究还表明，不同程度的反复缺氧对骨代谢有不同的影响，这一发现需要进一步研究。
