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Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases.血液来源和骨髓来源干细胞在非恶性疾病中的临床应用。
JAMA. 2008 Feb 27;299(8):925-36. doi: 10.1001/jama.299.8.925.
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Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism.由肿瘤坏死因子-α、脂多糖或缺氧刺激的人间充质干细胞通过核因子κB而非应激活化蛋白激酶依赖性机制产生生长因子。
Am J Physiol Cell Physiol. 2008 Mar;294(3):C675-82. doi: 10.1152/ajpcell.00437.2007. Epub 2008 Jan 30.
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Temporal changes in stem cells in the circulation and myocardium of mice with Coxsackie virus B3-induced myocarditis.柯萨奇病毒B3诱导的心肌炎小鼠循环系统和心肌中干细胞的时间变化。
Microvasc Res. 2008 Apr;75(3):358-66. doi: 10.1016/j.mvr.2007.10.005. Epub 2007 Nov 9.
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Short intensive exercise increases the migratory activity of mesenchymal stem cells.
Br J Sports Med. 2009 Mar;43(3):195-8. doi: 10.1136/bjsm.2007.043208. Epub 2007 Dec 10.
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Mesenchymal stem cells attenuate hypoxic pulmonary vasoconstriction by a paracrine mechanism.间充质干细胞通过旁分泌机制减弱缺氧性肺血管收缩。
J Surg Res. 2007 Dec;143(2):281-5. doi: 10.1016/j.jss.2006.11.006. Epub 2007 Sep 14.
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Rat model of chronic recurrent airway obstructions to study the sleep apnea syndrome.用于研究睡眠呼吸暂停综合征的慢性复发性气道阻塞大鼠模型。
Sleep. 2007 Jul;30(7):930-3. doi: 10.1093/sleep/30.7.930.
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Sleep-disordered breathing and cardiovascular risk.睡眠呼吸障碍与心血管风险。
Sleep. 2007 Mar;30(3):291-303. doi: 10.1093/sleep/30.3.291.
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Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice.骨髓间充质干细胞对小鼠内毒素诱导的全身反应的预防作用
Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L131-41. doi: 10.1152/ajplung.00431.2006. Epub 2007 Apr 6.
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Recurrent obstructive apneas trigger early systemic inflammation in a rat model of sleep apnea.复发性阻塞性呼吸暂停在睡眠呼吸暂停大鼠模型中引发早期全身炎症。
Respir Physiol Neurobiol. 2007 Jan 15;155(1):93-6. doi: 10.1016/j.resp.2006.06.004. Epub 2006 Oct 5.
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Multipotential mesenchymal stem cells are mobilized into peripheral blood by hypoxia.多能间充质干细胞通过缺氧被动员到外周血中。
Stem Cells. 2006 Oct;24(10):2202-8. doi: 10.1634/stemcells.2006-0164. Epub 2006 Jun 15.

阻塞性呼吸暂停会促使间充质干细胞早期释放到循环血液中。

Obstructive apneas induce early release of mesenchymal stem cells into circulating blood.

作者信息

Carreras Alba, Almendros Isaac, Acerbi Irene, Montserrat Josep M, Navajas Daniel, Farré Ramon

机构信息

Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona--IDIBAPS, Barcelona, Spain.

出版信息

Sleep. 2009 Jan;32(1):117-9.

PMID:19189787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2625316/
Abstract

STUDY OBJECTIVES

To investigate whether noninvasive application of recurrent airway obstructions induces early release of mesenchymal stem cells into the circulating blood in a rat model of obstructive sleep apnea.

DESIGN

Prospective controlled animal study.

SETTING

University laboratory.

PATIENTS OR PARTICIPANTS

Twenty male Sprague-Dawley rats (250-300 g).

INTERVENTIONS

A specially designed nasal mask was applied to the anesthetized rats. Ten rats were subjected to a pattern of recurrent obstructive apneas (60 per hour, lasting 15 seconds each) for 5 hours. Ten anesthetized rats were used as controls.

MEASUREMENTS AND RESULTS

Mesenchymal stem cells from the blood and bone marrow samples were isolated and cultured to count the total number of colony-forming unit fibroblasts (CFU-F) of adherent cells after 9 days in culture. The number of CFU-F from circulating blood was significantly (P = 0.02) higher in the rats subjected to recurrent obstructive apneas (5.00 +/- 1.16; mean +/- SEM) than in controls (1.70 +/- 0.72). No significant (P = 0.54) differences were observed in CFU-F from bone marrow.

CONCLUSIONS

Application of a pattern of airway obstructions similar to those experienced by patients with sleep apnea induced an early mobilization of mesenchymal stem cells into circulating blood.

摘要

研究目的

在阻塞性睡眠呼吸暂停大鼠模型中，研究反复气道阻塞的无创应用是否会诱导间充质干细胞早期释放到循环血液中。

设计

前瞻性对照动物研究。

地点

大学实验室。

患者或参与者

20只雄性斯普拉格-道利大鼠（250 - 300克）。

干预措施

将一个特别设计的鼻罩应用于麻醉的大鼠。10只大鼠接受反复阻塞性呼吸暂停模式（每小时60次，每次持续15秒），持续5小时。10只麻醉大鼠作为对照。

测量和结果

分离并培养血液和骨髓样本中的间充质干细胞，以计算培养9天后贴壁细胞的成纤维细胞集落形成单位（CFU - F）总数。反复阻塞性呼吸暂停的大鼠循环血液中的CFU - F数量（5.00 +/- 1.16；平均值 +/- 标准误）显著高于对照组（1.70 +/- 0.72）（P = 0.02）。骨髓中的CFU - F未观察到显著差异（P = 0.54）。

结论

应用类似于睡眠呼吸暂停患者所经历的气道阻塞模式可诱导间充质干细胞早期动员到循环血液中。