高效液相色谱法测定血浆中的地尔硫䓬及其主要代谢物N-单去甲基地尔硫䓬和去乙酰基地尔硫䓬。 - Suppr

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超能文献

High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma.

作者信息

Montamat S C, Abernethy D R, Mitchell J R

出版信息

J Chromatogr. 1987 Mar 20;415(1):203-7. doi: 10.1016/s0378-4347(00)83211-9.

DOI:10.1016/s0378-4347(00)83211-9

PMID:3584358

Abstract

摘要

相似文献

High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma.高效液相色谱法测定血浆中的地尔硫䓬及其主要代谢物N-单去甲基地尔硫䓬和去乙酰基地尔硫䓬。

J Chromatogr. 1987 Mar 20;415(1):203-7. doi: 10.1016/s0378-4347(00)83211-9.

Analysis of diltiazem and desacetyldiltiazem in plasma using modified high-performance liquid chromatography: improved sensitivity and reproducibility.使用改良高效液相色谱法分析血浆中的地尔硫䓬和去乙酰基地尔硫䓬：提高灵敏度和重现性。

Pharm Res. 1989 May;6(5):428-30. doi: 10.1023/a:1015943801775.

Quantitation of diltiazem and desacetyldiltiazem in dog plasma by high-performance liquid chromatography.

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Liquid chromatographic determination of diltiazem and its metabolites using trans isomers as internal standards, with dynamic modification of the solid phase by addition of an amine to the mobile phase.

J Chromatogr. 1987 Feb 20;414(1):109-20. doi: 10.1016/0378-4347(87)80029-4.

High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column.使用短链烷基硅烷醇去活柱，通过高效液相色谱法测定血浆中的地尔硫䓬及其两种代谢物。

J Chromatogr. 1993 May 19;615(1):111-6. doi: 10.1016/0378-4347(93)80296-g.

Simultaneous assay of propranolol, diltiazem and metabolites of diltiazem in human plasma by liquid chromatography.液相色谱法同时测定人血浆中普萘洛尔、地尔硫䓬及其代谢物

J Pharm Biomed Anal. 1990;8(6):535-9. doi: 10.1016/0731-7085(90)80064-v.

N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives.N-单去甲基地尔硫䓬是地尔硫䓬在年轻及老年高血压患者血浆中的主要代谢产物。

Br J Clin Pharmacol. 1987 Aug;24(2):185-9. doi: 10.1111/j.1365-2125.1987.tb03160.x.

Analysis of diltiazem and desacetyldiltiazem in serum by high-performance liquid chromatography.

Pol J Pharmacol. 1995 Sep-Oct;47(5):429-34.

High-performance liquid chromatographic determination of diltiazem and four of its metabolites in plasma: evaluation of their stability.

J Chromatogr. 1988 Aug 19;430(1):103-11. doi: 10.1016/s0378-4347(00)83138-2.

High-performance liquid chromatographic assay of diltiazem and six of its metabolites in plasma: application to a pharmacokinetic study in healthy volunteers.

J Pharm Sci. 1989 Jul;78(7):592-7. doi: 10.1002/jps.2600780718.

引用本文的文献

Br J Clin Pharmacol. 1987 Aug;24(2):185-9. doi: 10.1111/j.1365-2125.1987.tb03160.x.

Bioinequivalence of marketed diltiazem preparations.市售地尔硫䓬制剂的生物不等效性。

Eur J Clin Pharmacol. 1990;39(2):189-90. doi: 10.1007/BF00280058.

Diltiazem. A reappraisal of its pharmacological properties and therapeutic use.地尔硫䓬。对其药理特性和治疗用途的重新评估。

Drugs. 1990 May;39(5):757-806. doi: 10.2165/00003495-199039050-00009.

Decreased systemic clearance of diltiazem with increased hepatic metabolism in rats with uranyl nitrate-induced acute renal failure.硝酸铀酰诱导的急性肾衰竭大鼠中，地尔硫䓬的全身清除率降低，肝脏代谢增加。

Pharm Res. 1992 Dec;9(12):1599-606. doi: 10.1023/a:1015868525978.

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