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三维可视化技术在复杂肝内胆管结石肝切除术中的价值:一项倾向评分匹配研究。

The value of three-dimensional visualization techniques in hepatectomy for complicated hepatolithiasis: A propensity score matching study.

作者信息

Guo Qi, Chen Jiangming, Pu Tian, Zhao Yijun, Xie Kun, Geng Xiaoping, Liu Fubao

机构信息

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, China.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, China.

出版信息

Asian J Surg. 2023 Feb;46(2):767-773. doi: 10.1016/j.asjsur.2022.07.005. Epub 2022 Jul 15.

Abstract

OBJECTIVE

The present study aimed to investigate the safety, feasibility, and efficacy of three-dimensional visualization technique (3DVT)-guided hepatectomy in the treatment of complicated hepatolithiasis.

METHODS

The clinical and follow-up data of 279 patients with complicated hepatolithiasis were retrospectively analyzed. The patients were divided into a 3DVT group (group A, 66 cases) and a non-3DVT group (group B, 213 cases). After baseline data were balanced using propensity score matching (PSM), the clinical characteristics and follow-up data of the two groups were observed.

RESULTS

After 1:1 PSM, 58 patients in each group were successfully matched with each other. When the groups were compared, the surgical duration (p = 0.033) and intraoperative blood loss (p = 0.002) of group A were lower than those of group B. The immediate stone clearance rate (91.4% vs. 75.9%, p = 0.024) and quality of life outcome (p = 0.034) of group A were significantly higher than those of group B. Logistic regression analysis showed that history of two or more biliary tract operations (odds ratio [OR] = 6.544, 95% confidence interval [CI] = 1.193-35.890, p = 0.031), bilateral stone distribution (OR = 4.198, 95% CI = 1.186-14.854, p = 0.026), and Geng grade III or IV (OR = 12.262, 95% CI = 2.224-67.617, p = 0.004) were independent risk factors for poor outcomes in patients with complicated hepatolithiasis.

CONCLUSION

Compared to conventional imaging examinations, 3DVT can be used to guide and achieve accurate preoperative diagnosis of complicated hepatolithiasis and has good safety, feasibility, and efficacy.

摘要

目的

本研究旨在探讨三维可视化技术(3DVT)引导下肝切除术治疗复杂性肝内胆管结石的安全性、可行性及疗效。

方法

回顾性分析279例复杂性肝内胆管结石患者的临床及随访资料。将患者分为3DVT组(A组,66例)和非3DVT组(B组,213例)。采用倾向评分匹配(PSM)平衡基线数据后,观察两组的临床特征及随访资料。

结果

经1:1 PSM后,每组58例患者成功匹配。组间比较,A组手术时间(p = 0.033)及术中出血量(p = 0.002)均低于B组。A组即时结石清除率(91.4% 对75.9%,p = 0.024)及生活质量结局(p = 0.034)均显著高于B组。Logistic回归分析显示,两次及以上胆道手术史(比值比[OR]=6.544,95%置信区间[CI]=1.193 - 35.890,p = 0.031)、双侧结石分布(OR = 4.198,95% CI = 1.186 - 14.854,p = 0.026)及耿氏分级III或IV级(OR = 12.262,95% CI = 2.224 - 67.617,p = 0.004)是复杂性肝内胆管结石患者预后不良的独立危险因素。

结论

与传统影像学检查相比,3DVT可用于指导并实现复杂性肝内胆管结石的准确术前诊断,且具有良好的安全性、可行性及疗效。

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