Brumsted J R, Chapitis J, Riddick D, Gibson M
J Clin Endocrinol Metab. 1987 Jul;65(1):194-7. doi: 10.1210/jcem-65-1-194.
A woman with severe hyperandrogenemia and virilization was found to have a fall in serum testosterone (T) concentration while taking an oral contraceptive containing norethindrone (500 vs. 164 ng/dL). Subsequent surgical exploration revealed an ovarian Sertoli-Leydig cell tumor. In vitro, the tumor secreted T (mean, 1.88 ng/mg X 4 h). hCG did not stimulate T secretion. In addition, norethindrone inhibited T secretion (0.33 ng/mg X 4 h). We conclude that norethindrone directly suppressed T production by the Sertoli-Leydig cell tumor.
一名患有严重高雄激素血症和男性化的女性在服用含有炔诺酮的口服避孕药时，血清睾酮（T）浓度下降（从500 ng/dL降至164 ng/dL）。随后的手术探查发现了一个卵巢支持-间质细胞瘤。在体外，该肿瘤分泌睾酮（平均为1.88 ng/mg×4小时）。人绒毛膜促性腺激素（hCG）未刺激睾酮分泌。此外，炔诺酮抑制了睾酮分泌（0.33 ng/mg×4小时）。我们得出结论，炔诺酮直接抑制了支持-间质细胞瘤产生睾酮。
