[The association between stress hyperglycemia ratio and outcome of patients with acute ischemic stroke undergoing endovascular treatment].

To investigate the correlation between stress hyperglycemia ratio (SHR) and outcomes in patients with acute ischemic stroke treated with endovascular treatment. In a multicenter registration study for RESCUE-RE (a registration study for critical care of acute ischemic stroke after recanalization), eligible patients with large vessel occlusion stroke within 24 hours after onset who received endovascular treatment between July 2018 and May 2019 were enrolled. SHR was calculated as the fasting glucose concentration divided by the estimated average glucose concentration and then categorized into four groups according to the quartiles (group , group , group and group ). The primary outcome was poor neurological outcomeat day 90 fromstroke onset [defined as modified Rankin scale (mRS) of 3-6]. Secondary outcomes included early neurological deterioration (END), death within 3 months after stroke onset, and symptomatic intracranial hemorrhage.Multivariable logistic and Cox regression modelswere used to assess the correlation between quartiles of SHR and prognosis in patients with endovascular treatment. A total of 592 patients were enrolled in the study, with a mean age of (63±12) years, and 68.07% were male.The median National Institute of Health stroke scale(NIHSS) score on admission was15(11, 20), and the median SHR was 1.23 (1.07, 1.47), with SHR<1.07 in group , 1.07≤SHR<1.23 in group , 1.23≤SHR<1.47 in group and SHR≥1.47 in group , respectively. The rate of complete recanalization was lower in group than that of group (70.27% vs 83.67%, =0.026). After fully adjusted for potential covariates, the risk of poor neurological outcome at day 90 from stroke onset in group was 2.38 folds that of group (adjusted = 2.38, 95%: 1.57-3.57,=0.003). The risk of death within 3 months of patients in group was 1.80 times that of the patients in group , but the difference was not statistically significant(adjusted =1.80, 95%: 0.90-3.62, =0.098). Higher SHR was correlated with poor neurological outcome at 3 months in large artery occlusion related acute ischemic stroke patients receiving endovascular therapy.