Phillips Joseph R, Matar Elie, Ehgoetz Martens Kaylena A, Moustafa Ahmed A, Halliday Glenda M, Lewis Simon J G
Faculty of Medicine and Health, Brain and Mind Centre and Central Clinical School University of Sydney Sydney New South Wales Australia.
School of Psychology & Marcs Institute for Brain and Behaviour Western Sydney University Sydney New South Wales Australia.
Mov Disord Clin Pract. 2022 Jun 13;9(5):619-627. doi: 10.1002/mdc3.13488. eCollection 2022 Jul.
Dementia with Lewy bodies (DLB) is a common cause of dementia with poor prognosis and high hospitalization rates. DLB is frequently misdiagnosed, with clinical features that overlap significantly with other diseases including Parkinson's disease (PD). Clinical instruments that discriminate and track the progression of cognitive impairment in DLB are needed.
The current study was designed to assess the utility of a mental rotation (MR) task for assessing visuospatial impairments in early DLB.
Accuracy of 22 DLB patients, 22 PD patients and 22 age-matched healthy controls in the MR task were compared at comparing shapes with 0°, 45° and 90° rotations.
Healthy controls and PD patients performed at similar levels while the DLB group were significantly impaired. Further, impairment in the visuospatial and executive function measures correlated with MR poor outcomes.
These findings support the MR task as an objective measure of visuospatial impairment with the ability to adjust difficulty to suit impairments in a DLB population. This would be a useful tool within clinical trials.
路易体痴呆（DLB）是痴呆的常见病因，预后较差且住院率高。DLB常被误诊，其临床特征与包括帕金森病（PD）在内的其他疾病有显著重叠。需要能够鉴别和追踪DLB认知障碍进展的临床工具。
本研究旨在评估心理旋转（MR）任务在评估早期DLB视觉空间障碍中的效用。
比较了22例DLB患者、22例PD患者和22例年龄匹配的健康对照在MR任务中比较0°、45°和90°旋转形状时的准确性。
健康对照和PD患者表现水平相似，而DLB组明显受损。此外，视觉空间和执行功能测量的损伤与MR任务的不良结果相关。
这些发现支持将MR任务作为视觉空间损伤的客观测量方法，该方法有能力调整难度以适应DLB人群的损伤情况。这将是临床试验中的一个有用工具。
