Department of Nursing, Shanghai General Hospital, Shanghai 200080, China.
Comput Math Methods Med. 2022 Jul 8;2022:2942982. doi: 10.1155/2022/2942982. eCollection 2022.
This study is aimed at investigating the influences of oral administration of probiotics on posthepatectomy recovery in patients in Child-Pugh grade.
100 patients (50 cases in Child-Pugh A grade and 50 cases in Child-Pugh B grade) underwent hepatectomy in our hospital from January 2018 to January 2020 were involved in this study. Subsequently, Child-Pugh A grade and Child-Pugh B grade patients were set as probiotics group (taking Clostridium butyricum, = 25) and control group (no probiotics, = 25). The general information, infectious indexes, and liver function indexes on days 1, 3, and 5 after operation were collected.
In Child-Pugh B grade subgroup patients, the procalcitonin, alanine aminotransferase, and prothrombin time of the probiotics group were statistically significantly lower than that of the control group on days 3 ( < 0.05) and 5 ( < 0.05) after surgery. In Child-Pugh A grade subgroup patients, there were no significant differences between probiotics group and control group after operation.
Child-Pugh A grade subgroup patients with hepatectomy could not benefit from oral probiotics. However, Child-Pugh B grade subgroup patients taking probiotics after hepatectomy could reduce postoperative infection and accelerate recovery of liver function.
本研究旨在探讨口服益生菌对不同肝功能 Child-Pugh 分级患者肝切除术后恢复的影响。
选取 2018 年 1 月至 2020 年 1 月在我院行肝切除术的 100 例患者（Child-Pugh A 级 50 例，Child-Pugh B 级 50 例），将 Child-Pugh A 级和 Child-Pugh B 级患者分为益生菌组（服用酪酸梭菌，n=25）和对照组（未服用益生菌，n=25）。收集患者术后第 1、3、5 天的一般资料、感染指标和肝功能指标。
Child-Pugh B 级亚组患者术后第 3、5 天，益生菌组降钙素原、丙氨酸氨基转移酶、凝血酶原时间明显低于对照组（<0.05）。Child-Pugh A 级亚组患者术后两组间无明显差异。
Child-Pugh A 级肝切除术后患者不能从口服益生菌中获益。然而，Child-Pugh B 级肝切除术后患者服用益生菌可以降低术后感染，促进肝功能恢复。
