Dreskin S C, Goldsmith P K, Strober W, Zech L A, Gallin J I
J Clin Invest. 1987 Jun;79(6):1764-72. doi: 10.1172/JCI113017.
The metabolism of human IgE was studied in normals, severe atopics, and patients with the hyperimmunoglobulin E-recurrent infection (HIE; Job's) syndrome to determine whether IgE metabolism is altered in patients with marked elevation of serum IgE. Purified polyclonal 125I-IgE was administered intravenously and serial plasma and urine samples were obtained. After analysis, the metabolic data support previously published evidence that IgE (at concentrations found in normal individuals) is catabolized at a higher fractional rate than other immunoglobulins and is catabolized by both an intravascular and an extravascular pathway. In addition, the data show that the fractional catabolic rate for IgE is significantly less for the atopic patients (mean +/- SEM = 0.20 +/- 0.01) and for the HIE patients (0.15 +/- 0.02) than for the normal volunteers (0.52 +/- 0.06; P less than 0.01) and is inversely related (r = -0.851; P less than 0.001) to the serum IgE concentration. These findings have specific importance in showing that decreased fractional catabolic rate contributes substantially to elevation of IgE in atopic and HIE patients. In addition, the findings have general significance in that they lead to a unifying hypothesis of immunoglobulin catabolism.
对正常人、重度特应性皮炎患者以及高免疫球蛋白E复发性感染（HIE；乔布氏）综合征患者的人IgE代谢进行了研究，以确定血清IgE显著升高的患者中IgE代谢是否发生改变。静脉注射纯化的多克隆125I-IgE，并采集系列血浆和尿液样本。分析后，代谢数据支持先前发表的证据，即IgE（在正常个体中发现的浓度）以比其他免疫球蛋白更高的分解代谢率进行分解代谢，并且通过血管内和血管外途径进行分解代谢。此外，数据显示，特应性皮炎患者（均值±标准误=0.20±0.01）和HIE患者（0.15±0.02）的IgE分解代谢率分数显著低于正常志愿者（0.52±0.06；P<0.01），并且与血清IgE浓度呈负相关（r=-0.851；P<0.001）。这些发现对于表明分解代谢率分数降低在特应性皮炎和HIE患者的IgE升高中起重要作用具有特定意义。此外，这些发现具有普遍意义，因为它们导致了免疫球蛋白分解代谢的统一假说。
