Stewart W E, Lin L, Chudzio T, Wiranowska-Stewart M
Tex Rep Biol Med. 1977;35:193-7.
Interferons can be chemically and enzymatically altered to obtain molecular forms which differ in size, charge, and/or host-range from native interferons. These data suggest that small active cores of interferons can be obtained which may possess more desirable characteristics than native interferons, such as lack of "species-specificity"" and increased stabilities. Studies for assessing alterations of interferons due to chemical or enzymatic treatments must monitor the treated interferons for changes in ratios of each of the various activities attributed to native interferons and must characterize the altered interferons in terms of each of the physical and biological markers.
干扰素可通过化学和酶法进行改造，以获得在大小、电荷和/或宿主范围方面与天然干扰素不同的分子形式。这些数据表明，可以获得干扰素的小活性核心，其可能具有比天然干扰素更理想的特性，例如缺乏“种属特异性”和更高的稳定性。评估化学或酶处理导致的干扰素改变的研究必须监测处理后的干扰素，以观察归因于天然干扰素的各种活性的比例变化，并且必须根据每种物理和生物学标记来表征改变后的干扰素。
