通过测量血浆碱性磷酸酶同工酶活性鉴定乳腺癌的骨和肝转移
Identification of bone and liver metastases from breast cancer by measurement of plasma alkaline phosphatase isoenzyme activity.
作者信息
Mayne P D, Thakrar S, Rosalki S B, Foo A Y, Parbhoo S
出版信息
J Clin Pathol. 1987 Apr;40(4):398-403. doi: 10.1136/jcp.40.4.398.
Plasma alkaline phosphatase isoenzyme activities were determined in patients with breast cancer to diagnose and monitor bone and liver metastases. Bone alkaline phosphatase activity was increased in 21 of 50 patients (42%) with radiologically confirmed bone metastases, while total alkaline phosphatase activity was increased in only 10 of 50 (20%); liver alkaline phosphatase activity was raised in 12 of 25 patients (48%) with liver metastases. All patients with liver metastases had bone metastases. Bone alkaline phosphatase activity was significantly higher in patients with symptomatic bone disease. Isoenzyme determination provided additional information that would have changed patient management in five of 20 patients who were monitored serially. Measurement of alkaline phosphatase isoenzyme activity, though less sensitive than imaging procedures, can assist in screening for, and in early detection of, a high proportion of bone and liver metastases, and can provide useful objective evidence of their response to treatment.
测定了乳腺癌患者的血浆碱性磷酸酶同工酶活性，以诊断和监测骨转移和肝转移。在50例经放射学证实有骨转移的患者中，21例（42%）骨碱性磷酸酶活性升高，而50例中只有10例（20%）总碱性磷酸酶活性升高；在25例有肝转移的患者中，12例（48%）肝碱性磷酸酶活性升高。所有有肝转移的患者都有骨转移。有症状骨病的患者骨碱性磷酸酶活性明显更高。同工酶测定提供了额外信息，在连续监测的20例患者中有5例患者的治疗方案因此而改变。碱性磷酸酶同工酶活性的测定虽然不如影像学检查敏感，但有助于筛查和早期发现大部分骨转移和肝转移，并可为它们对治疗的反应提供有用的客观证据。
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