Viot M, Joulin C, Cambon P, Krebs B P, Schneider M, Lalanne C M
Biomedicine. 1979 Jun;31(3):74-7.
Serum alkaline phosphatase isoenzyme electrophoresis on cellulose acetate plates in a normal population of 91 controls and 255 cancer patients demonstrates the presence of an isoenzyme alpha 1 in 36 out of39 cases of confirmed liver metastases. In 188 cancer patients without apparent hepatic lesion and with a normal liver biology, the alpha 1 isoenzyme has been found in 45 cases, but 11 presented afterwards confirmed liver metastases. This isoenzyme remained negative in the normal population. Therefore, our results indicate that the alpha 1 alkaline phosphatase isoenzyme may be a useful marker for the biological diagnosis of liver metastases.
在91名对照者和255名癌症患者的正常人群中，在醋酸纤维素板上进行血清碱性磷酸酶同工酶电泳，结果显示，在39例确诊为肝转移的病例中，有36例存在α1同工酶。在188例无明显肝脏病变且肝脏生物学指标正常的癌症患者中，有45例发现了α1同工酶，但其中11例后来被确诊为肝转移。该同工酶在正常人群中呈阴性。因此，我们的结果表明，α1碱性磷酸酶同工酶可能是肝转移生物学诊断的一个有用标志物。
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