• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血管加压素V2受体拮抗剂对钙通道阻滞剂相关水肿合并血管痉挛性心绞痛的治疗潜力

Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina.

作者信息

Toda Kojiro, Fujino Masashi, Murai Kota, Noguchi Teruo

机构信息

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Centre, Suita, Japan.

出版信息

Case Rep Cardiol. 2022 Jul 8;2022:9550006. doi: 10.1155/2022/9550006. eCollection 2022.

DOI:10.1155/2022/9550006
PMID:35845175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9286935/
Abstract

Calcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin-angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-associated edema. A 78-year-old man had refractory edema induced by a CCB. It was successfully treated with tolvaptan, an active vasopressin V2 receptor antagonist. The aim of this case report is to understand the mechanism and treatment of CCB-associated peripheral edema and how tolvaptan affects peripheral edema.

摘要

钙通道阻滞剂（CCB）相关的外周性水肿若不停用CCB或降低剂量则不会消退。然而，有报道称肾素-血管紧张素系统（RAS）抑制剂对CCB相关的水肿有效。我们报告一例患有难治性CCB相关水肿的血管痉挛性心绞痛病例。一名78岁男性因CCB诱发难治性水肿。使用活性血管加压素V2受体拮抗剂托伐普坦成功治愈。本病例报告的目的是了解CCB相关外周性水肿的机制和治疗方法，以及托伐普坦如何影响外周性水肿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/e06e0dc9a94a/CRIC2022-9550006.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/96a1c5edd473/CRIC2022-9550006.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/c2ab003ef809/CRIC2022-9550006.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/f8bf83fe2702/CRIC2022-9550006.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/e06e0dc9a94a/CRIC2022-9550006.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/96a1c5edd473/CRIC2022-9550006.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/c2ab003ef809/CRIC2022-9550006.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/f8bf83fe2702/CRIC2022-9550006.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d2b/9286935/e06e0dc9a94a/CRIC2022-9550006.004.jpg

相似文献

1
Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina.血管加压素V2受体拮抗剂对钙通道阻滞剂相关水肿合并血管痉挛性心绞痛的治疗潜力
Case Rep Cardiol. 2022 Jul 8;2022:9550006. doi: 10.1155/2022/9550006. eCollection 2022.
2
Calcium channel blocker-related periperal edema: can it be resolved?钙通道阻滞剂相关的外周性水肿：能否得到解决？
J Clin Hypertens (Greenwich). 2003 Jul-Aug;5(4):291-4, 297. doi: 10.1111/j.1524-6175.2003.02402.x.
3
Vasopressin for persistent hypotension due to amlodipine and olmesartan overdose: A case report.血管加压素治疗氨氯地平和奥美沙坦过量导致的持续性低血压：一例报告
Ann Med Surg (Lond). 2021 Apr 15;65:102292. doi: 10.1016/j.amsu.2021.102292. eCollection 2021 May.
4
Optimizing management of hypertension with combination therapy: considerations for the nurse practitioner.联合治疗优化高血压管理：执业护士的考量因素
J Cardiovasc Nurs. 2009 Sep-Oct;24(5):380-9. doi: 10.1097/JCN.0b013e3181aed18e.
5
Magnitude of and Characteristics Associated With the Treatment of Calcium Channel Blocker-Induced Lower-Extremity Edema With Loop Diuretics.钙通道阻滞剂引起的下肢水肿用袢利尿剂治疗的程度和特征。
JAMA Netw Open. 2019 Dec 2;2(12):e1918425. doi: 10.1001/jamanetworkopen.2019.18425.
6
Development and Validation of a Medication Selection Model Under Clinical Application of Renin-Angiotensin Inhibitor Combined with Calcium Channel Blocker for Hypertension Patients.基于肾素-血管紧张素抑制剂联合钙通道阻滞剂在高血压患者临床应用的药物选择模型的建立与验证。
Med Sci Monit. 2020 Apr 14;26:e923696. doi: 10.12659/MSM.923696.
7
Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports.血管痉挛性心绞痛患者将品牌血管扩张剂换用通用血管扩张剂后心绞痛发作频率增加：两例病例报告。
World J Cardiol. 2018 Mar 26;10(3):15-20. doi: 10.4330/wjc.v10.i3.15.
8
Managing peripheral edema in patients with arterial hypertension.管理动脉高血压患者的外周水肿。
Am J Ther. 2009 Nov-Dec;16(6):543-53. doi: 10.1097/MJT.0b013e3181afbf9f.
9
Mitigation of calcium channel blocker-related oedema in hypertension by antagonists of the renin-angiotensin system.肾素-血管紧张素系统拮抗剂减轻高血压患者中钙通道阻滞剂相关水肿
J Hum Hypertens. 2009 Aug;23(8):503-11. doi: 10.1038/jhh.2008.157. Epub 2009 Jan 15.
10
Edematous Hyponatremia Treated with Tolvaptan in a Patient with Amyotrophic Lateral Sclerosis.托伐普坦治疗肌萎缩侧索硬化症患者的水肿性低钠血症
Electrolyte Blood Press. 2017 Dec;15(2):37-41. doi: 10.5049/EBP.2017.15.2.37. Epub 2017 Dec 31.

本文引用的文献

1
Tolvaptan Efficiently Reduces Intracellular Fluid: Working Toward a Potential Treatment Option for Cellular Edema.托伐普坦可有效减少细胞内液：迈向细胞水肿潜在治疗方案的研究进展
Intern Med. 2019 Mar 1;58(5):639-642. doi: 10.2169/internalmedicine.0993-18. Epub 2018 Nov 19.
2
S-Amlodipine: An Isomer with Difference-Time to Shift from Racemic Amlodipine.左旋氨氯地平：一种与消旋氨氯地平转变时间不同的异构体。
Int J Hypertens. 2018 May 20;2018:8681792. doi: 10.1155/2018/8681792. eCollection 2018.
3
Tolvaptan for Heart Failure in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis.
托伐普坦用于慢性肾脏病患者心力衰竭的系统评价和荟萃分析。
Heart Lung Circ. 2018 Aug;27(8):928-939. doi: 10.1016/j.hlc.2017.12.013. Epub 2018 Feb 13.
4
Dual Impact of Tolvaptan on Intracellular and Extracellular Water in Chronic Kidney Disease Patients with Fluid Retention.托伐普坦对伴有液体潴留的慢性肾脏病患者细胞内和细胞外水的双重影响
Intern Med. 2016;55(19):2759-2764. doi: 10.2169/internalmedicine.55.7133. Epub 2016 Oct 1.
5
Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema.血管紧张素系统阻滞剂对钙通道阻滞剂相关外周水肿的影响。
Am J Med. 2011 Feb;124(2):128-35. doi: 10.1016/j.amjmed.2010.08.007.
6
Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia.托伐普坦，一种选择性口服血管加压素V2受体拮抗剂，用于治疗低钠血症。
N Engl J Med. 2006 Nov 16;355(20):2099-112. doi: 10.1056/NEJMoa065181. Epub 2006 Nov 14.
7
Case studies in hypertension: managing calcium channel blocker-related peripheral edema.高血压病例研究：处理与钙通道阻滞剂相关的外周水肿
J Clin Hypertens (Greenwich). 2004 Jul;6(7):400-2. doi: 10.1111/j.1524-6175.2004.02863.x.
8
Vasodilatory edema: a common side effect of antihypertensive therapy.血管扩张性水肿：抗高血压治疗的常见副作用。
Curr Cardiol Rep. 2002 Nov;4(6):479-82. doi: 10.1007/s11886-002-0110-9.
9
Combined use of nifedipine and diltiazem for the treatment of severe hypertension.硝苯地平与地尔硫䓬联合用于治疗重度高血压。
South Med J. 1991 Apr;84(4):502-4. doi: 10.1097/00007611-199104000-00025.