Wei Linjie, Lin Chi, Xue Xingsen, Jila Shiju, Dai Yalan, Pan Li, Wei Wei, Dun Guodong, Shen Yong, Zong Taoxi, Wu Jingjing, Li Yafang, Wu Lixia, Xian Jishu, Yu Anyong
Department of Neurosurgery, PLA 956th Hospital, Linzhi, China.
Department of Neurosurgery, First People's Hospital of Honghe City, Honghe, China.
Front Hum Neurosci. 2022 Jun 30;16:834427. doi: 10.3389/fnhum.2022.834427. eCollection 2022.
The prognosis of hypertensive intracerebral hemorrhage (HICH) is poor at high altitudes. The objective of this study was to explore whether hyperbaric oxygen (HBO) can improve the results of computed tomography perfusion (CTP) imaging and the neurological function of patients with HICH, and influence the hemoglobin concentration.
The patients with HICH were treated with puncture and drainage. Twenty-one patients (51.22% of 41 patients in total) were treated with HBO after the operation, and the other patients received conventional treatment. CTP was performed twice, and all indices were measured. Scatter plots were used to determine the effect of hemoglobin concentration on CTP imaging. Receiver operating characteristic (ROC) curves were plotted to analyze the effects of hemoglobin concentration and hematoma volume on recovery results. The patients were followed up for 6 months.
Forty-one patients with HICH were treated with puncture and drainage. In total, 21 were treated with HBO after the operation, and 20 received conventional treatment as the control group. No significant differences in the CBV and CBF values of the two groups were noted before treatment. After 10 days, the values of CBV and CBF in the HBO group were significantly higher than those in the control group. A scatter diagram showed there was no significant in the HBO group, but significant correlation for the CBV and CBF values in the control group's hematoma center and margin. The ROC curves showed that hematoma volume had an influence on prognosis of the control group. The Glasgow Coma Scale (GOS) scores of the HBO group were significantly higher than those of the control group ( < 0.05).
HBO therapy can improve the postoperative CBV and CBF values of patients with HICH and ameliorate their prognoses. There was no significant correlation between HBO group and hemoglobin concentration on admission.
高原地区高血压性脑出血（HICH）预后较差。本研究旨在探讨高压氧（HBO）能否改善HICH患者的计算机断层扫描灌注（CTP）成像结果及神经功能，并影响血红蛋白浓度。
对HICH患者行穿刺引流治疗。术后21例患者（共41例患者的51.22%）接受HBO治疗，其余患者接受常规治疗。进行两次CTP检查，并测量所有指标。采用散点图确定血红蛋白浓度对CTP成像的影响。绘制受试者工作特征（ROC）曲线分析血红蛋白浓度和血肿体积对恢复结果的影响。对患者进行6个月的随访。
41例HICH患者接受穿刺引流治疗。其中21例术后接受HBO治疗，20例接受常规治疗作为对照组。治疗前两组的脑血容量（CBV）和脑血流量（CBF）值无显著差异。10天后，HBO组的CBV和CBF值显著高于对照组。散点图显示HBO组无显著相关性，但对照组血肿中心和边缘的CBV和CBF值存在显著相关性。ROC曲线显示血肿体积对对照组的预后有影响。HBO组的格拉斯哥昏迷量表（GOS）评分显著高于对照组（<0.05）。
HBO治疗可改善HICH患者术后的CBV和CBF值，改善其预后。HBO组与入院时血红蛋白浓度无显著相关性。
