来自志愿非亲属供者细胞的急性髓系白血病伴…… （原文不完整，翻译至此）
Volunteer unrelated donor cell-derived acute myeloid leukemia with .
作者信息
Hagiwara Shinya, Kusumoto Shigeru, Ito Asahi, Masaki Ayako, Shiraga Kazuhide, Tachita Takuto, Hirade Kentaro, Oiwa Kana, Suzuki Tomotaka, Kinoshita Shiori, Ri Masaki, Ito Yasuhiko, Komatsu Hirokazu, Inagaki Hiroshi, Iida Shinsuke
机构信息
Department of Hematology and Oncology Nagoya City University Graduate School of Medical Sciences Nagoya Japan.
Department of Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences Nagoya Japan.
出版信息
EJHaem. 2021 Feb 9;2(2):285-290. doi: 10.1002/jha2.169. eCollection 2021 May.
A 15-year-old male was diagnosed with acute myeloid leukemia with t(6;9)(p23;q34), a chimeric - fusion gene. He underwent allogeneic bone marrow transplantation (allo-BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo-BMT, multiple bone marrow aspirations showed increased blasts to 63%, which were positive for myeloperoxidase, CD13, CD33, CD56, and CD34. Surprisingly, t(8;21)(q22;q22.1), a chimeric (not fusion gene, was detected with full donor chimerism. To our best knowledge, this is the first case of a volunteer unrelated donor cell-derived acute myeloid leukemia harboring a chimeric fusion gene.
一名15岁男性被诊断为患有伴有t(6;9)(p23;q34)（一种嵌合融合基因）的急性髓系白血病。他在首次分子缓解时接受了来自一名无关志愿供者的异基因骨髓移植（allo-BMT）。allo-BMT后约5年，多次骨髓穿刺显示原始细胞增加至63%，这些原始细胞髓过氧化物酶、CD13、CD33、CD56和CD34呈阳性。令人惊讶的是，检测到伴有完全供者嵌合现象的t(8;21)(q22;q22.1)（一种嵌合而非融合基因）。据我们所知，这是首例由志愿无关供者细胞衍生的、携带有嵌合融合基因的急性髓系白血病病例。
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