Li Yuejin, Shi Fengxue, Wang Guanglei, Lv Jian, Zhang Haitao, Jin Hao, Chen Xueyu, Wang Meng, Li Peirui, Ji Long
Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining, China.
School of Clinical, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Front Mol Neurosci. 2022 Jul 1;15:843897. doi: 10.3389/fnmol.2022.843897. eCollection 2022.
Epilepsy is a chronic brain disease that recurs during childhood, and more than half of adult epilepsy originates from childhood. Studies suggested that immunoglobulin G (IgG) glycosylation are closely related to neurological diseases. Here we analyzed the characteristics of the immunoglobulin glycosylation profile of children with epilepsy.
Patients were recruited in Taian, Shandong Province from December 2019 to March 2020. Serum IgG glycome composition was analyzed by hydrophilic interaction liquid chromatography with ultra-high-performance liquid chromatography approach.
The proportion of fucosylated glycans in total IgG glycans was 93.72% in the epilepsy patients, which was significantly lower than that in the control group (94.94%). A lower level of total monogalactosylated and digalactosylated glycans were observed in the epilepsy patients group (30.76 and 40.14%) than that in the controls (36.17 and 42.69%). There was no significant difference between the two groups in bisected GlcNAc glycans and sialylated glycans.
The decrease of core fucosylation and galactosylation may promote the inflammatory reaction of the body and participate in the occurrence of epilepsy in children.
癫痫是一种在儿童期复发的慢性脑部疾病，超过半数的成人癫痫起源于儿童期。研究表明，免疫球蛋白G（IgG）糖基化与神经系统疾病密切相关。在此，我们分析了癫痫患儿免疫球蛋白糖基化谱的特征。
2019年12月至2020年3月在山东省泰安市招募患者。采用亲水相互作用液相色谱结合超高效液相色谱法分析血清IgG糖组成分。
癫痫患者总IgG聚糖中岩藻糖基化聚糖的比例为93.72%，显著低于对照组（94.94%）。癫痫患者组中总单半乳糖基化和双半乳糖基化聚糖水平（分别为30.76%和40.14%）低于对照组（分别为36.17%和42.69%）。两组在平分型N-乙酰葡糖胺聚糖和唾液酸化聚糖方面无显著差异。
核心岩藻糖基化和半乳糖基化的减少可能促进机体的炎症反应，并参与儿童癫痫的发生。
