Alleviates Obesity by Altering the Composition of the Gut Microbiota in High-Fat Diet-Fed Mice.

Metabolic disorders and intestinal flora imbalance usually accompany obesity. Due to its diverse biological activities, is widely used to alleviate various diseases as a probiotic. Here, we show that can reduce the body weight of mice fed high-fat diets, reduce fat accumulation, and enhance mice glucose tolerance. Our results show that can significantly reduce the expression of DGAT1 and DGAT2, increase the expression of Cpt1a, and promote the process of lipid metabolism. Further data show that can increase the SCFA content in the colon and reverse the intestinal flora disorder caused by HFD, increase the abundance of , and , and reduce the abundance of and . Finally, through Pearson correlation analysis, we found that and SCFAs are positively correlated, while are negatively correlated with SCFAs. Therefore, we believe that can regulate the structure of the intestinal microbial community, increase the production of SCFAs and thus regulate lipid metabolism.