Green P G, Kennedy C T, Forbes D R
J Am Acad Dermatol. 1987 May;16(5 Pt 1):984-8. doi: 10.1016/s0190-9622(87)70125-x.
The stability of anthralin in white soft paraffin, Lassar's paste, and Unguentum Merck was assessed using a sensitive assay for degradation products, over a 1-year period. The stability was found to vary with concentration, weaker preparations being less stable. Significant degradation was observed in Unguentum Merck, and this increased when salicylic acid was present. Preparations with Unguentum Merck could be stabilized with ascorbic or oxalic acid. Salicylic acid stabilized anthralin in Lassar's paste but had a negligible effect in white soft paraffin. Preparations with white soft paraffin were relatively stable.
采用一种针对降解产物的灵敏检测方法，在一年时间内评估了蒽林在白软石蜡、拉萨尔糊剂和默克软膏中的稳定性。结果发现稳定性随浓度而变化，浓度较低的制剂稳定性较差。在默克软膏中观察到显著降解，当存在水杨酸时降解增加。含默克软膏的制剂可用抗坏血酸或草酸使其稳定。水杨酸可使拉萨尔糊剂中的蒽林稳定，但在白软石蜡中作用可忽略不计。含白软石蜡的制剂相对稳定。
