孕期成人T细胞白血病/淋巴瘤（ATL）：英国病例系列
Adult T cell leukaemia/lymphoma (ATL) in pregnancy: A UK case series.
作者信息
Motedayen Aval Leila, Boullier Mary, Lyall Hermione, Collins Graham P, Ayto Robert, Kelly Dominic F, Tedder Richard S, Drysdale Simon B, Taylor Graham P, Cook Lucy B
机构信息
Section of Virology, Imperial College London UK.
Department of Paediatrics St George's University Hospitals NHS Foundation Trust London UK.
出版信息
EJHaem. 2020 Nov 25;2(1):131-135. doi: 10.1002/jha2.142. eCollection 2021 Feb.
Abstract
INTRODUCTION
Chronic infection with human T-cell lymphotropic virus type-1 (HTLV-1) may result in aggressive adult T-cell leukaemia/lymphoma (ATL) in 4-6% carriers. The majority of this risk arises in carriers infected during infancy, and so each infant has ∼25% lifetime risk. Other risk factors include a family history of ATL. Antenatal HTLV-1 screening is not undertaken in the UK.
METHODS
Here we describe four cases of ATL diagnosed during pregnancy and describe strategies to minimise HTLV-1 transmission to neonates.
RESULTS/CONCLUSION: These cases highlight undiagnosed HTLV-1 in pregnancy which allows ongoing mother to child vertical transmission and risk of future ATL. We recommend the UK National Screening Committee incorporate HTLV-1 serology into antenatal screening.
摘要
引言
人类嗜T淋巴细胞病毒1型（HTLV-1）慢性感染可导致4%-6%的携带者患侵袭性成人T细胞白血病/淋巴瘤（ATL）。这种风险大部分出现在婴儿期感染的携带者中，因此每个婴儿一生中有约25%的风险。其他风险因素包括ATL家族史。英国不进行产前HTLV-1筛查。
方法
在此我们描述了4例孕期诊断为ATL的病例，并描述了将HTLV-1传播给新生儿的风险降至最低的策略。
结果/结论：这些病例凸显了孕期未诊断出的HTLV-1感染，这使得母婴垂直传播持续存在，并增加了未来患ATL的风险。我们建议英国国家筛查委员会将HTLV-1血清学纳入产前筛查。
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