Komatsu Nahoko, Iwanaga Masako, Hasegawa Yuri, Miura Shoko, Fuchi Naoki, Moriuchi Hiroyuki, Yanagihara Katsunori, Miura Kiyonori
Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Clinical Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Front Microbiol. 2022 Nov 15;13:1036955. doi: 10.3389/fmicb.2022.1036955. eCollection 2022.
Human T-cell leukemia virus type-1 (HTLV-1) is transmitted vertically from an infected mother to her child breastfeeding during infancy or horizontally sexual contact. However, little information is available on the HTLV-1 seroconversion rate in pregnant mothers and the impact of new HTLV-1 infection on mothers and babies during the perinatal period.
From the database of a prefecture-wide antenatal adult T-cell leukemia prevention program in Nagasaki, Japan, we extracted data on 57,323 pregnant women who were screened for anti-HTLV-1 antibody during 2011-2018. Data on the 16,863 subjects whose HTLV-1 proviral load (PVL) was measured more than twice were included in our analyses.
In total, 133 (0.79%) pregnant women were HTLV-1-positive during their first pregnancy and nine (0.05%) seroconverted before or during subsequent pregnancies (between pregnancies). The median PVL (per 100 peripheral blood mononuclear cells) was significantly lower in the seroconverted mothers (0.10%) than in the initially seropositive mothers (0.15%). A repeated measures correlation analysis for the individual PVLs of the HTLV-1-positive pregnant women showed that PVL increased with parity number ( = 0.25) with no perinatal problems.
The HTLV-1 seroconversion rate between pregnancies was 0.05%, and their HTLV-1 PVL increased annually but no perinatal problems were noted.
人类T细胞白血病病毒1型（HTLV-1）可通过母婴垂直传播，即感染的母亲在婴儿期通过母乳喂养将病毒传给孩子，也可通过性接触水平传播。然而，关于孕妇中HTLV-1血清转化率以及围产期新的HTLV-1感染对母亲和婴儿的影响，目前所知甚少。
从日本长崎一项全县范围的成人T细胞白血病产前预防项目数据库中，我们提取了2011年至2018年期间接受抗HTLV-1抗体筛查的57323名孕妇的数据。对HTLV-1前病毒载量（PVL）测量超过两次的16863名受试者的数据进行了分析。
共有133名（0.79%）孕妇在首次怀孕时HTLV-1呈阳性，9名（0.05%）在随后的怀孕前或怀孕期间（两次怀孕之间）发生了血清转化。血清转化的母亲的中位PVL（每100个外周血单个核细胞）（0.10%）显著低于最初血清阳性的母亲（0.15%）。对HTLV-1阳性孕妇的个体PVL进行重复测量相关性分析表明，PVL随着产次增加（r = 0.25），且没有围产期问题。
两次怀孕之间的HTLV-1血清转化率为0.05%，她们的HTLV-1 PVL逐年增加，但未发现围产期问题。
