抗逆转录病毒疗法对艾滋病毒/艾滋病感染者心脏风险标志物的影响。

Effect of antiretroviral therapy on cardiac risk markers in people living with HIV/AIDS.

作者信息

Gupta Pulin Kumar, Tyagi Saurabh, Sheoran Ankita, Jain Princi, Koner Sai Kiran, Sharma Lokesh Kumar, Singh Saurabh Kumar, Khura Jayanti

机构信息

Department of Medicine, Atal Bihari Vajpayee Institute of Medical Sciences, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Department of Biochemistry, Atal Bihari Vajpayee Institute of Medical Sciences, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

出版信息

Indian J Sex Transm Dis AIDS. 2022 Jan-Jun;43(1):52-55. doi: 10.4103/ijstd.ijstd_72_21. Epub 2022 Jun 7.

DOI:10.4103/ijstd.ijstd_72_21

PMID:35846544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9282697/

Abstract

INTRODUCTION

Chronic HIV infection and antiretroviral therapy (ART) are the major causes of cardiovascular diseases (CVDs) and mortality in HIV patients. This study was conducted to look upon the effect of ART on CVD risk markers in patients on different ART regimens and ART-naïve patients.

METHODS

It was a cross-sectional, observational study done on 120 HIV-infected patients. CV risk markers were assessed and correlated with disease-specific factors within individual subgroups differentiated as Group A (ART naïve), Group B (first-line ART), and Group C (second-line ART). Carotid intimal medial thickness (CIMT) and high-sensitivity C reactive protein (hsCRP) were done to classify cases as having CVD.

RESULTS

CVD risk parameters were found to be significantly higher in cases on ART, as compared to ART-naïve cases. The mean CIMT among cases in Group C, Group B, and Group A was 0.072 ± 0.01 cm, 0.063 ± 0.01 cm, and 0.055 ± 0.01 cm, respectively ( < 0.01). 95%, 65% and 25% cases in Group C, Group B, and Group A, respectively, had high CIMT (>0.06 cm) and were seen to be directly correlated with disease-related factors, i.e., duration of disease and ART, type of ART, and low CD4 cell counts. hsCRP was significantly increased in 65 out of total 120 cases. The mean hsCRP in Group A, Group B, and Group C was 3.69 ± 3.37, 4.21 ± 3.4, and 5.72 ± 3.54 mg/L, respectively ( < 0.01), which corresponds to the high risk of CVD.

CONCLUSION

CVD risk parameters of CIMT and hsCRP are seen to be higher in patients on ART than ART-naive subjects.

摘要

引言

慢性HIV感染和抗逆转录病毒疗法（ART）是HIV患者心血管疾病（CVD）和死亡的主要原因。本研究旨在观察ART对接受不同ART方案的患者以及未接受过ART治疗的患者心血管疾病风险标志物的影响。

方法

这是一项对120例HIV感染患者进行的横断面观察性研究。评估心血管疾病风险标志物，并将其与分为A组（未接受过ART治疗）、B组（一线ART治疗）和C组（二线ART治疗）的各个亚组内的疾病特异性因素进行关联分析。通过测量颈动脉内膜中层厚度（CIMT）和高敏C反应蛋白（hsCRP）来将病例分类为患有心血管疾病。

结果

与未接受过ART治疗的病例相比，接受ART治疗的病例的心血管疾病风险参数显著更高。C组、B组和A组病例的平均CIMT分别为0.072±0.01厘米、0.063±0.01厘米和0.055±0.01厘米（<0.01）。C组、B组和A组分别有95%、65%和25%的病例CIMT较高（>0.06厘米），并且被发现与疾病相关因素直接相关，即疾病持续时间和ART治疗、ART治疗类型以及低CD4细胞计数。120例病例中有65例hsCRP显著升高。A组、B组和C组的平均hsCRP分别为3.69±3.37、4.21±3.4和5.72±3.54毫克/升（<0.01），这对应着较高的心血管疾病风险。