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B94 在预防和治疗大鼠肝损伤中的作用及机制。

Effect and Mechanism of B94 in the Prevention and Treatment of Liver Injury in Rats.

机构信息

Department of Rehabilitation Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.

出版信息

Front Cell Infect Microbiol. 2022 Jun 29;12:914684. doi: 10.3389/fcimb.2022.914684. eCollection 2022.

DOI:10.3389/fcimb.2022.914684
PMID:35846768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9277360/
Abstract

OBJECTIVE

To investigate the effect of B94 on the prevention and treatment of liver injury in rats and to elucidate the underlying mechanism of this relationship.

METHODS

Specific pathogen-free (SPF) rats were selected as the healthy control group, liver injury group and B94 treatment group, with 6 rats in each group. After the model was established, the experimental animals were tested for serum liver function indicators, gut microbiota composition, metabolite composition, and histopathology.

RESULTS

The albumin/globulin ratio and serum TBA, alanine aminotransferase, aspartate aminotransferase, and indirect bilirubin levels in the B94 treatment group were significantly lower than those in the liver injury group. 16S rRNA analysis showed that the gut microbiota of the three groups of rats were significantly different. Metabolic profile analysis showed that there were significant differences in the gut metabolomes of the three groups. Haematoxylin-eosin staining of the intestinal mucosa and liver tissues showed that the degree of liver and intestinal tissue damage in the B94 treatment group was significantly lower than that in the liver injury group.

CONCLUSION

B94 can affect the process of liver injury in rats by improving liver function, reducing intestinal damage, and regulating gut microbiota and metabolite production.

摘要

目的

研究 B94 对大鼠肝损伤的防治作用，并阐明其作用机制。

方法

选择 SPF 大鼠作为健康对照组、肝损伤组和 B94 治疗组，每组 6 只。造模后，检测各组大鼠血清肝功能指标、肠道微生物组成、代谢物组成和组织病理学变化。

结果

B94 治疗组大鼠的白蛋白/球蛋白比值及血清总胆汁酸、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、间接胆红素水平明显低于肝损伤组。16S rRNA 分析显示，三组大鼠的肠道菌群存在明显差异。代谢组学分析显示，三组大鼠的肠道代谢物谱存在明显差异。肝组织和肠黏膜组织苏木精-伊红染色显示，B94 治疗组大鼠的肝、肠组织损伤程度明显低于肝损伤组。

结论

B94 可通过改善肝功能、减轻肠道损伤、调节肠道菌群和代谢产物生成，影响大鼠肝损伤的发生发展过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/3b77f6362912/fcimb-12-914684-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/b534a270ee4d/fcimb-12-914684-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/989c584b6336/fcimb-12-914684-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/9562d9a528d7/fcimb-12-914684-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/7682443884bf/fcimb-12-914684-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/703796c4176e/fcimb-12-914684-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/3b77f6362912/fcimb-12-914684-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/b534a270ee4d/fcimb-12-914684-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/989c584b6336/fcimb-12-914684-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/9562d9a528d7/fcimb-12-914684-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/7682443884bf/fcimb-12-914684-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/703796c4176e/fcimb-12-914684-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7be1/9277360/3b77f6362912/fcimb-12-914684-g006.jpg

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