Pop Cristina, Cristina Anamaria, Iaru Irina, Popa Stefan L, Mogoșan Cristina
Department of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
2nd Medical Department, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Front Pharmacol. 2022 Jul 1;13:952562. doi: 10.3389/fphar.2022.952562. eCollection 2022.
Pharmacogenetics (PGx) is an important component of personalized medicine that has the potential to improve medicines' effectiveness and safety. However, despite progress in technology and availability, PGx testing application into patient-care in Eastern Europe countries, has been slow. Our aim was to describe knowledge and attitudes of Romanian pharmacists concerning PGx, and identify potential factors limiting PGx implementation. An anonymous, web-based questionnaire was distributed to Romanian pharmacists registered in the National Pharmacists' Association (NPA) an official e-mail sent by NPA representatives. A total of 1,058 pharmacists completed the questionnaires, resulting in a response rate of 7.6%. Pharmacists were predominantly female (90.1%), younger than 49 years (87.5%) and mostly worked in community pharmacies (80.2%). Most pharmacists (64.8%) had a knowledge score between 30 and 49 points out of 60, and (75.4%) had attitude scores between 9 and 7 out of 10. Attitude and knowledge scores positively correlated. Despite performing fairly well on general questions regarding PGx, Romanian pharmacists may lack in-depth knowledge, which can affect their readiness to discuss PGx information with patients or other healthcare professionals. High pricing was considered an important impediment in PGx implementation.
药物遗传学（PGx）是个性化医疗的一个重要组成部分，它有可能提高药物的有效性和安全性。然而，尽管在技术和可及性方面取得了进展，但PGx检测在东欧国家患者护理中的应用一直很缓慢。我们的目的是描述罗马尼亚药剂师对PGx的了解和态度，并确定限制PGx实施的潜在因素。通过向在国家药剂师协会（NPA）注册的罗马尼亚药剂师发放一份基于网络的匿名调查问卷，并由NPA代表发送官方电子邮件。共有1058名药剂师完成了问卷，回复率为7.6%。药剂师主要为女性（90.1%），年龄小于49岁（87.5%），且大多在社区药房工作（80.2%）。大多数药剂师（64.8%）在60分的知识测试中得分在30至49分之间，（75.4%）在10分的态度测试中得分在9至7分之间。态度得分与知识得分呈正相关。尽管罗马尼亚药剂师在关于PGx的一般问题上表现尚可，但他们可能缺乏深入的知识，这可能会影响他们与患者或其他医疗保健专业人员讨论PGx信息的意愿。高昂的价格被认为是PGx实施的一个重要障碍。
