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DNA/RNA heteroduplex oligonucleotides: An unanticipated twist in the delivery of ASOs.

作者信息

Setten Ryan L, Dowdy Steven F

机构信息

Department of Cellular & Molecular Medicine, University of California San Diego, School of Medicine, La Jolla, CA, USA.

出版信息

Mol Ther Nucleic Acids. 2022 Jul 1;29:133-134. doi: 10.1016/j.omtn.2022.06.013. eCollection 2022 Sep 13.

DOI:10.1016/j.omtn.2022.06.013
PMID:35847172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9256975/
Abstract
摘要

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Delivery of RNA Therapeutics: The Great Endosomal Escape!RNA 治疗药物的递送：伟大的内体逃逸！
Nucleic Acid Ther. 2022 Oct;32(5):361-368. doi: 10.1089/nat.2022.0004. Epub 2022 May 24.
2
The Role of Long Noncoding RNA MALAT1 in Diabetic Polyneuropathy and the Impact of Its Silencing in the Dorsal Root Ganglion by a DNA/RNA Heteroduplex Oligonucleotide.长链非编码 RNA MALAT1 在糖尿病多发性神经病中的作用及其通过 DNA/RNA 杂合寡核苷酸在背根神经节中沉默的影响。
Diabetes. 2022 Jun 1;71(6):1299-1312. doi: 10.2337/db21-0918.
3
Regulation of activated microglia and macrophages by systemically administered DNA/RNA heteroduplex oligonucleotides.系统给予 DNA/RNA 杂合双链寡核苷酸对激活的小神经胶质细胞和巨噬细胞的调节作用。
Mol Ther. 2022 Jun 1;30(6):2210-2223. doi: 10.1016/j.ymthe.2022.02.019. Epub 2022 Feb 18.
4
DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo.用于体内调节淋巴细胞的DNA/RNA异源双链寡核苷酸技术
Nat Commun. 2021 Dec 22;12(1):7344. doi: 10.1038/s41467-021-26902-8.
5
Challenges and Opportunities for Nucleic Acid Therapeutics.核酸治疗的挑战与机遇
Nucleic Acid Ther. 2022 Feb;32(1):8-13. doi: 10.1089/nat.2021.0085. Epub 2021 Dec 17.
6
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.胆固醇功能化的 DNA/RNA 杂合双链可穿过血脑屏障并敲低啮齿动物中枢神经系统中的基因。
Nat Biotechnol. 2021 Dec;39(12):1529-1536. doi: 10.1038/s41587-021-00972-x. Epub 2021 Aug 12.
7
Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice.静脉注射α-生育酚偶联的异源双链寡核苷酸在小鼠中有效沉默缺血性脑卒中后的 miR-126。
Sci Rep. 2021 Jul 9;11(1):14237. doi: 10.1038/s41598-021-93666-y.
8
Delivery of oligonucleotide-based therapeutics: challenges and opportunities.寡核苷酸类治疗药物的递送：挑战与机遇。
EMBO Mol Med. 2021 Apr 9;13(4):e13243. doi: 10.15252/emmm.202013243. Epub 2021 Apr 6.
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