Alabdulbaqi Manar, Toupin Melissa, Berardi Philip, McCurdy Arleigh
Department of Hematology The Ottawa Hospital Ottawa Ontario Canada.
Department of Hematology Ottawa Hospital General Campus Ottawa Ontario Canada.
EJHaem. 2020 Jul 10;1(1):364-367. doi: 10.1002/jha2.13. eCollection 2020 Jul.
We report a case of a 45-year-old female who developed an ALK-positive anaplastic large cell lymphoma (ALCL) 9 years after renal transplant. The patient underwent a cadaveric renal transplant for diabetic nephropathy, and presented 9 years later with fever and multiorgan dysfunction. The initial CT scans showed multiple enlarged supra- and infradiaphrgamatic lymph nodes. A CT-guided core needle biopsy of a retroperitoneal lymph node revealed ALK positive ALCL. She received six cycles of cyclophosphamide, adriamycin, vincristine, etoposide, and prednisone, and has been in remission for over 3 years. Monomorphic T-cell posttransplant lymphoproliferative disorder (PTLD) is an established but rare entity of PTLD and generally carries poor prognosis. This is a case report of a late PTLD with pathology reporting an aggressive T-cell lymphoma that has been successfully treated with multiagent chemotherapy.
我们报告一例45岁女性患者，该患者在肾移植9年后发生ALK阳性间变性大细胞淋巴瘤（ALCL）。该患者因糖尿病肾病接受了尸体肾移植，9年后出现发热和多器官功能障碍。最初的CT扫描显示双侧膈肌上下多个肿大淋巴结。经CT引导对一个腹膜后淋巴结进行粗针活检，结果显示为ALK阳性ALCL。她接受了六个周期的环磷酰胺、阿霉素、长春新碱、依托泊苷和泼尼松治疗，目前已缓解超过3年。单形性T细胞移植后淋巴增殖性疾病（PTLD）是一种已明确但罕见的PTLD类型，通常预后较差。这是一例晚期PTLD的病例报告，其病理报告为侵袭性T细胞淋巴瘤，已通过多药化疗成功治疗。
