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仅用抗生素成功治疗婴儿肋骨骨髓炎。

Successful Treatment with Antibiotics Alone for Infant Rib Osteomyelitis.

作者信息

Matsumoto Yasuaki, Shimozawa Katsuyoshi, Yamanaka Junko, Atsumi Yukari, Ota Tomomi, Mochizuki Shinji, Shichino Hiroyuki

机构信息

Department of Pediatrics, National Center for Global Health and Medicine Hospital, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.

Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1 Oyaguchikami-cho, Itabashi-ku, Tokyo 173-8610, Japan.

出版信息

Case Rep Pediatr. 2022 Jun 8;2022:3093784. doi: 10.1155/2022/3093784. eCollection 2022.

Abstract

Pediatric rib osteomyelitis is a rare disease occurring predominantly in the neonatal period and early childhood and accounting for about 1% of all pediatric osteomyelitis. Compared to osteomyelitis in other parts of the body, pediatric rib osteomyelitis shows few localized findings (such as redness and swelling) and often an indolent lesion as well either of which may delay diagnosis and thus make treatment more difficult. A previously healthy one-year-old girl came to our department with a chief complaint of fever lasting for three days. She was admitted to our department to investigate her fever. At the time of admission, radiographs showed decreased permeability in the left lung field; so, we started antimicrobial therapy on the assumption of pneumonia. On the second day of admission, methicillin-susceptible was detected in the blood culture. A further, more detailed physical examination revealed some slight left anterior chest swelling. We performed a contrast-enhanced CT scan and an MRI and diagnosed her with rib osteomyelitis complicated with a chest wall abscess. She was given intravenous cefazolin for two weeks, switched to oral cephalexin for four weeks, and then recovered completely. She was treated without surgical intervention, having showed a good response to antimicrobial therapy. Osteomyelitis of the ribs in children is reported to be more common in the lower ribs and to occur more frequently in infants. In many cases, the earliest symptoms are nonspecific, so careful examination to detect any subtle abnormalities-such as swelling or mass-is of key importance for early diagnosis in infants. Regarding treatment, most cases of hematogenous osteomyelitis resolve with antimicrobial therapy alone-although surgical intervention may be required in cases of poor response to antimicrobial therapy. Therefore, early diagnosis of rib osteomyelitis through careful physical examination may reduce the chances of requiring surgical intervention.

摘要

小儿肋骨骨髓炎是一种罕见疾病,主要发生在新生儿期和幼儿期,约占所有小儿骨髓炎的1%。与身体其他部位的骨髓炎相比,小儿肋骨骨髓炎的局部表现(如红肿)较少,且常为隐匿性病变,这两者都可能延迟诊断,从而使治疗更加困难。一名此前健康的1岁女童因持续发热3天前来我院就诊。她被收入我院以调查发热原因。入院时,胸部X光片显示左肺野透亮度降低;因此,我们基于肺炎的假设开始了抗菌治疗。入院第二天,血培养检测到对甲氧西林敏感的[细菌名称未给出]。进一步更详细的体格检查发现左前胸有轻微肿胀。我们进行了增强CT扫描和MRI检查,诊断她为肋骨骨髓炎合并胸壁脓肿。她接受了两周的静脉注射头孢唑林治疗,之后改为口服头孢氨苄四周,然后完全康复。她未接受手术干预,对抗菌治疗反应良好。据报道,儿童肋骨骨髓炎在下肋骨更为常见,且在婴儿中更易发生。在许多情况下,最早的症状是非特异性的,因此仔细检查以发现任何细微异常(如肿胀或肿块)对于婴儿的早期诊断至关重要。关于治疗,大多数血源性骨髓炎病例仅通过抗菌治疗即可痊愈——尽管对抗菌治疗反应不佳的病例可能需要手术干预。因此,通过仔细的体格检查早期诊断肋骨骨髓炎可能会减少需要手术干预的几率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/9277467/5f9d1682cd7b/CRIPE2022-3093784.001.jpg

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