Department of Geriatrics, Florida State University College of Medicine, Tallahassee, FL, USA.
Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, FL, USA.
J Alzheimers Dis. 2022;89(1):87-105. doi: 10.3233/JAD-220319.
Subjective cognitive decline (SCD) is related to personality functioning and risk of subsequent objective cognitive impairment.
The aim of this study was to examine whether lower neuroticism and higher conscientiousness-resilient personality traits-protect against conversion from SCD to objective cognitive impairment in two longitudinal community-based cohorts.
Data from the Health and Retirement Study (N = 1,741, Mean age = 68.64 years, Follow-up mean = 7.34 years) and the National Health and Aging Trends Survey (N = 258, Mean age = 79.34 years, Follow-up mean = 4.31 years) were analyzed using Cox regression analysis, controlling for sociodemographic covariates, symptoms of anxiety and depression, and apolipoprotein ɛ4.
The pooled results showed that lower neuroticism and higher conscientiousness were associated with decreased risk of conversion from SCD to objective cognitive impairment.
Among individuals with SCD, those with a resilient personality may have more cognitive and psychological reserve to maintain cognitive functioning and delay conversion to objective cognitive impairment. The findings further contribute to a better understanding of personality along the cognitive continuum: The observed effect sizes were smaller than those reported in cognitively normal individuals but larger than in individuals with mild cognitive impairment. Personality could provide useful information to identify individuals with SCD who may develop objective cognitive impairment-namely those who hold a vulnerable personality (higher neuroticism, lower conscientiousness).
主观认知衰退（SCD）与人格功能有关，并且与随后发生客观认知障碍的风险相关。
本研究旨在检验在两个纵向社区队列中，较低的神经质和较高的尽责性-韧性人格特质是否可以预防从 SCD 向客观认知障碍的转变。
使用 Cox 回归分析，对来自健康与退休研究（N=1741，平均年龄 68.64 岁，随访平均 7.34 年）和国家健康与老龄化趋势调查（N=258，平均年龄 79.34 岁，随访平均 4.31 年）的数据进行分析，控制了社会人口统计学协变量、焦虑和抑郁症状以及载脂蛋白 E4。
汇总结果表明，较低的神经质和较高的尽责性与从 SCD 向客观认知障碍的转变风险降低相关。
在 SCD 个体中，具有韧性人格的个体可能具有更多的认知和心理储备，以维持认知功能并延缓向客观认知障碍的转变。这些发现进一步加深了我们对认知连续体中人格的理解：观察到的效应大小小于在认知正常个体中报告的效应大小，但大于在轻度认知障碍个体中报告的效应大小。人格可以提供有用的信息，以识别可能发生客观认知障碍的 SCD 个体，即具有脆弱人格（较高的神经质、较低的尽责性）的个体。
