Gretchen Reynolds PhD, 60 Fenwood Road, Boston MA 02115, USA, Email:
J Prev Alzheimers Dis. 2022;9(3):435-440. doi: 10.14283/jpad.2022.31.
With the increasing focus on prevention of Alzheimer's disease, there is need for characterization of preclinical populations. Local participant registries offer an opportunity to facilitate research engagement via remote data collection, inform recruitment, and characterize preclinical samples, including individuals with subjective cognitive decline.
We sought to characterize subjective cognitive decline in a registry sample, as related to psychiatric history and related variables, including personality and loneliness, quality of life, and factors related to dementia risk (e.g., family history of dementia).
DESIGN, SETTING, PARTICIPANTS: Participants were 366 individuals (mean age=67.2 (range 50-88), 65% female, 94% white, 97% non-Hispanic or Latino, 82% with at least a bachelor's degree) with no reported history of mild cognitive impairment or dementia. All participants had expressed interest in research, primarily via community outreach events and prior research involvement. Data was collected via electronic surveys, distributed using REDCap. Electronic questionnaires included questions on demographic variables, subjective cognitive decline, quality of life, loneliness, and personality.
There was a high prevalence of risk factors for dementia in the registry sample (68% with family history of dementia, 31% with subjective cognitive decline). Subjective cognitive decline was more common in women and associated with history of depression, but not with family history of dementia. Subjective cognitive decline was also associated with lower conscientiousness and lower emotional stability, as well as higher loneliness and lower quality of life. Among participants who endorsed a psychiatric history, most reported onset more than 10 years prior, rather than within the last 10 years.
Subjective cognitive decline in a registry sample may be more strongly associated with longstanding psychiatric and personality variables, rather than family history of dementia, adding to the literature on characterization of subjective cognitive decline across different settings. These findings highlight the acceptability of remote data collection and the potential of registries to inform recruitment by characterizing registrants, which may help to stratify dementia risk and match participants to eligible trials.
随着对阿尔茨海默病预防的关注度不断提高，需要对临床前人群进行特征描述。当地参与者登记处提供了通过远程数据收集促进研究参与、提供招募信息和描述临床前样本的机会，包括有主观认知下降的个体。
我们旨在描述登记处样本中的主观认知下降，以及与精神病史和相关变量（包括个性和孤独感、生活质量以及与痴呆风险相关的因素（例如，痴呆家族史））的关系。
设计、地点和参与者：参与者为 366 名个体（平均年龄 67.2 岁（范围 50-88 岁），65%为女性，94%为白人，97%为非西班牙裔或拉丁裔，82%至少拥有学士学位），均无轻度认知障碍或痴呆的报告史。所有参与者都对研究表示有兴趣，主要是通过社区外展活动和之前的研究参与。数据通过电子调查收集，使用 REDCap 分发。电子问卷包括人口统计学变量、主观认知下降、生活质量、孤独感和个性等问题。
登记处样本中存在多种痴呆风险因素（68%有痴呆家族史，31%有主观认知下降）。女性中主观认知下降更为常见，与抑郁史有关，但与痴呆家族史无关。主观认知下降还与较低的尽责性和较低的情绪稳定性以及较高的孤独感和较低的生活质量有关。在有精神病史的参与者中，大多数人报告发病时间超过 10 年，而不是在过去 10 年内。
登记处样本中的主观认知下降可能与长期的精神病史和个性变量关系更为密切，而不是与痴呆家族史相关，这为不同环境下主观认知下降的特征描述增添了文献依据。这些发现突出了远程数据收集的可接受性以及登记处通过描述登记者为招募提供信息的潜力，这可能有助于分层痴呆风险并将参与者与合格试验相匹配。
