Department of Obstetrics and Gynecology, College of Medicine, University of Al-Qadisiyah, Iraq;
J Popul Ther Clin Pharmacol. 2022 Jun 8;29(2):e11-e19. doi: 10.47750/jptcp.2022.916. eCollection 2022.
Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder, affecting 5-10% of females with hyperandrogenism and prolonged anovulation.
This study was done to understand the serum leptin role in women with PCOS and its link with the body mass index (BMI) and insulin resistance (IR).
This 1-year study was conducted in the Departments of Obstetrics and Gynecology as well as Infertility Unite in AL-Diwaniyah Maternity and Pediatrics Teaching Hospital, Iraq, in which 40 patients with PCOS (study group) and 40 healthy (non-PCOS) patients (control group) participated. After BMI assessment, both the study and control groups were further stratified into subgroups as normal weight and overweight patients. Blood samples were obtained for all patients for the serum leptin level (SLL), fasting blood glucose (FBG), and serum insulin level. The HOMA-IR equation was used to estimate insulin resistance for all patients.
SLL of the PCOS women (mean ± SD, 22.29 ± 10.96 ng/ml) was significantly (P < 0.05) higher (17.89 ± 8.29 ng/ml) when compared to that of the control group. Insulin level was significantly elevated in the obese control and PCOS women (16.87 ± 3.52) µ UI/L and (15.09 ± 5.27) µUI, respectively, compared to normal BMI control and PCOS patients (P ≤ 0.01). Insulin resistance was significantly higher in obese (control and PCOS) patients (2.47 ± 0.40 and 2.30 ± 0.43, respectively), compared to normal BMI (control and PCOS) patients (P ≤ 0.01).
In obese patients, serum leptin significantly correlated with BMI in the presence of hyperinsulinemia and elevated insulin resistance.
多囊卵巢综合征（PCOS）是一种常见的异质性内分泌紊乱，影响 5-10%的高雄激素和排卵延长的女性。
本研究旨在了解多囊卵巢综合征患者血清瘦素的作用及其与体重指数（BMI）和胰岛素抵抗（IR）的关系。
这项为期 1 年的研究在伊拉克迪亚瓦尼耶妇产医院妇产科和不孕不育科进行，其中 40 名多囊卵巢综合征患者（研究组）和 40 名健康（非多囊卵巢综合征）患者（对照组）参与。在评估 BMI 后，研究组和对照组进一步分为正常体重和超重患者亚组。所有患者均采集血样检测血清瘦素水平（SLL）、空腹血糖（FBG）和血清胰岛素水平。所有患者均采用 HOMA-IR 方程估计胰岛素抵抗。
多囊卵巢综合征女性的 SLL（平均值 ± 标准差，22.29 ± 10.96 ng/ml）明显高于对照组（17.89 ± 8.29 ng/ml）（P < 0.05）。肥胖对照组和多囊卵巢综合征女性的胰岛素水平明显升高（16.87 ± 3.52）µUI/L和（15.09 ± 5.27）µUI，与正常 BMI 对照组和多囊卵巢综合征患者相比（P ≤ 0.01）。肥胖（对照组和多囊卵巢综合征）患者的胰岛素抵抗明显高于正常 BMI（对照组和多囊卵巢综合征）患者（2.47 ± 0.40 和 2.30 ± 0.43）（P ≤ 0.01）。
在肥胖患者中，血清瘦素与高胰岛素血症和胰岛素抵抗升高时与 BMI 显著相关。
