State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, China.
Nat Prod Res. 2023 Mar;37(6):967-973. doi: 10.1080/14786419.2022.2101052. Epub 2022 Jul 18.
Sorghum ( L.) is the fifth largest crop in the world and has potential health benefits, but vast quantities of sorghum roots are discarded after harvest. Based on the previous antiplatelet aggregation for this species, two new -substituted 3-indole alkaloids sorghumine A () and sorghumine B (), together with 14 known compounds (), were found from the water extract of sorghum roots. Compounds - were identified by analyzing their spectroscopic data and physic and chemical properties, and the absolute configuration was further determined by electronic circular dichroism (ECD) analysis and calculations. -, , - and - showed significant inhibition of platelet aggregation induced by adenosine diphosphate. -, - and showed significant inhibition of platelet aggregation induced by collagen. -, , - and showed significant inhibition on platelet aggregation induced by thrombin. Furthermore, molecular docking showed that active compounds can bind to P2Y12 and COX-1 receptors in platelet.
高粱（Sorghum）是世界上第五大作物，具有潜在的健康益处，但大量高粱根在收获后被丢弃。基于该物种先前的抗血小板聚集作用，从高粱根的水提取物中发现了两种新的 -取代的 3-吲哚生物碱高粱胺 A（）和高粱胺 B（），以及 14 种已知化合物（）。化合物 - 通过分析其光谱数据和物理化学性质进行鉴定，绝对构型进一步通过电子圆二色性（ECD）分析和计算确定。- 、 - 、- 和 - 对由二磷酸腺苷诱导的血小板聚集具有显著的抑制作用。- 、- 和 对由胶原诱导的血小板聚集具有显著的抑制作用。- 、- 、- 和 对由凝血酶诱导的血小板聚集具有显著的抑制作用。此外，分子对接表明，活性化合物可以与血小板中的 P2Y12 和 COX-1 受体结合。
