Aldrich L B, Sisson J C, Grum C M
J Endocrinol Invest. 1987 Apr;10(2):111-6. doi: 10.1007/BF03347168.
Pulmonary testing was carried out in 12 of 35 consecutive cases of differentiated thyroid carcinoma metastatic to the lung, which were identified in a retrospective analysis covering the 22-yr period from 1962-1984. In 7 of the 12 patients, pulmonary function tests showed abnormalities. Impaired pulmonary function was associated with a poor prognosis. Four of the twelve patients died; each had impaired pulmonary function and their ages (12-65 yr) were similar to those still living (13-65 yr). Specific types of functional abnormalities were not associated with pulmonary metastases, and underlying pulmonary disease contributed to the findings in some patients. Four patterns were defined on chest radiographs: macronodular, micronodular, miliary, and normal, but these patterns did not correlate with outcome. Scintiscan patterns varied from normal to diffuse concentration of 131I. Generally, following therapy with radioiodine, fewer abnormalities on chest x-ray and less uptake of 131I in the lungs was noted. However, therapy with radioiodine did not improve pulmonary function. Pulmonary function testing appears to be a better predictor of outcome in patients with thyroid carcinoma metastatic to lung than chest x-ray appearance or scintigraphic scanning.
在1962年至1984年的22年回顾性分析中确诊的35例分化型甲状腺癌肺转移的连续病例中，对其中12例进行了肺功能测试。12例患者中有7例肺功能测试显示异常。肺功能受损与预后不良相关。12例患者中有4例死亡；他们均有肺功能受损，年龄（12至65岁）与仍存活患者（13至65岁）相似。特定类型的功能异常与肺转移无关，一些患者的基础肺部疾病导致了这些检查结果。胸部X光片上定义了四种模式：大结节型、小结节型、粟粒型和正常型，但这些模式与预后无关。闪烁扫描模式从正常到131I弥漫性浓聚不等。一般来说，放射性碘治疗后，胸部X光片上的异常减少，肺部131I摄取减少。然而，放射性碘治疗并未改善肺功能。对于甲状腺癌肺转移患者，肺功能测试似乎比胸部X光表现或闪烁扫描更能预测预后。
