通过对 772 只鹅的全基因组重测序鉴定翅膀长度相关性状的关键候选基因。

Identification of key candidate genes for wing length-related traits by whole-genome resequencing in 772 geese.

School of Life Science, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.

Br Poult Sci. 2022 Dec;63(6):747-753. doi: 10.1080/00071668.2022.2102889. Epub 2022 Aug 15.

Abstract

A total of 772, 420-day-old Xingguo grey geese (XGG) were sequenced using a low-depth (~1 x) whole-genome resequencing strategy to reveal the genetic mechanism of wing length-related traits by genome-wide association analysis (GWAS).2. The results showed that 119 SNPs had genome-wide significance for wing length in five regions of chromosome 4, of which the most significant locus (P = 7.95E-11) was located upstream of and explained 7.3% of the phenotypic variation.3. A total of 219 SNPs located on chromosome 4 were associated with 2-joint-wing length, of which four SNPs reached the genome-wide significant level. However, for the length of 1-joint-wing and primary feather, we did not detect any associated locus.4. Six promising candidate genes, and on chromosome 4, may play an important role in the growth and development of feathers, muscles and bones.

摘要

本研究采用低深度（~1x）全基因组重测序策略对 772420 日龄兴国灰鹅进行测序，通过全基因组关联分析（GWAS）揭示与翼长相关性状的遗传机制。
结果表明，在第 4 号染色体的 5 个区域，有 119 个 SNP 与翼长具有全基因组显著关联，其中最显著的位点（P=7.95E-11）位于上游，解释了 7.3%的表型变异。
总共 219 个位于第 4 号染色体上的 SNP 与 2-关节翼长相关，其中 4 个 SNP 达到全基因组显著水平。然而，对于 1-关节翼长和初级羽毛，我们没有检测到任何相关的基因座。
第 4 号染色体上的 6 个有希望的候选基因、和可能在羽毛、肌肉和骨骼的生长和发育中发挥重要作用。