Barrat J, Cabrol D, Chouraqui A, Crépin G, Dumez Y, Hacker R, Henrion R, Magnin G, Soutoul J H, Sureau C
J Gynecol Obstet Biol Reprod (Paris). 1987;16(1):93-9.
The authors used sulprostone on 165 women whose pregnancies had lasted more than 12 weeks. The principal indications were: intra-uterine fetal deaths in 65 cases and an antenatal diagnosis of fetal malformations in 75 cases. Three routes of administration of the drug were employed: extra-amniotic in 15 women; intravenous in 62 women; intramuscular in 88 women. The doses used (adding together the intramuscular and intravenous routes) were: ampoule of 500 micrograms of sulprostone in 25% of cases; ampoules in 50% of cases; ampoules in 25% of cases. It was found to be very effective: by the intravenous route 88.70% expelled the fetus in 24 hours with a mean induction delivery time of 11 hours; by the intramuscular route 89.77% expelled in 24 hours with a mean induction delivery time of 11 hours 45 minutes. The side effects were not common: nausea in 17.6%; vomiting in 16.4% and diarrhoea in 6%. Ther marked effectiveness of sulprostone on the one hand and the good tolerance on the other indicate the effects of this product, which are a strong action on the uterus and a feeble action on the smooth muscle of other organs.
作者对165名妊娠超过12周的女性使用了磺前列酮。主要适应症为：65例宫内死胎和75例产前诊断胎儿畸形。采用了三种给药途径：15名女性羊膜外给药；62名女性静脉给药；88名女性肌肉注射给药。所使用的剂量（肌肉注射和静脉注射途径相加）为：25%的病例使用500微克磺前列酮安瓿；50%的病例使用安瓿；25%的病例使用安瓿。结果发现其非常有效：静脉给药途径88.70%的患者在24小时内排出胎儿，平均引产分娩时间为11小时；肌肉注射途径89.77%的患者在24小时内排出胎儿，平均引产分娩时间为11小时45分钟。副作用并不常见：恶心占17.6%；呕吐占16.4%；腹泻占6%。磺前列酮一方面显著有效，另一方面耐受性良好，表明了该产品的作用，即对子宫有强烈作用，对其他器官的平滑肌作用较弱。
