Trustwell Hospitals, Bengaluru, Karnataka, India.
Rangadore Memorial Hospital, Bengaluru, Karnataka, India.
Eur Arch Otorhinolaryngol. 2023 Feb;280(2):713-721. doi: 10.1007/s00405-022-07544-y. Epub 2022 Jul 18.
To comprehensively analyse the disease presentation and mortality of COVID-associated rhino-orbito-cerebral mucormycosis.
A retrospective analysis of the demographics, clinical and radiographic findings was performed. A binary logistic regression analysis was performed to examine the survival of patients with mucormycosis from hypothesised predictors.
A total of 202 patients were included in this study. Statistical significance was demonstrated in the predilection to the male gender, recent history of SARS-COV-2, history of use of corticosteroid and hyperglycemia in this cohort of CAM. The mortality rate was 18.31%. Advanced age, raised HbA1c and intra-orbital extension were found to be predictors adversely affecting survival.
Early diagnosis, aggressive surgical therapy, early and appropriate medical therapy can help improve outcomes.
Level 4.
全面分析 COVID 相关的鼻-眶-脑毛霉菌病的临床表现和死亡率。
对人口统计学、临床和影像学发现进行回顾性分析。对毛霉菌病患者的生存情况进行二元逻辑回归分析，以检验假设预测因子。
本研究共纳入 202 例患者。在该 CAM 队列中，男性倾向、最近 SARS-COV-2 史、皮质类固醇使用史和高血糖具有统计学意义。死亡率为 18.31%。高龄、糖化血红蛋白升高和眶内延伸被发现是影响生存的不利预测因素。
早期诊断、积极的手术治疗、早期和适当的药物治疗有助于改善预后。
4 级。
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