脱脂卡介苗热水提取物的抗肿瘤活性。
Antitumor activity of hot-water extract from delipidated BCG.
作者信息
Sato H, Yokosawa A, Arai H, Nagai H, Kumano N, Motomiya M, Konno K
出版信息
Tohoku J Exp Med. 1978 Jul;125(3):247-52. doi: 10.1620/tjem.125.247.
The antitumor activity of hot-water extract of delipidated BCG was investigated in mice inoculated with Sarcoma-180 cells and Ehrlich carcinoma cells, respectively. The hot-water extract was found to be effective when administered after and ineffective when administered before the inoculation of tumor cells. When this extract was given with anticancer drugs, such as Mitomycin C and cyclophosphamide, a combined effect was obtained in the treatment of Sarcoma-180 and of Ehrlich carcinoma.
分别在接种肉瘤-180细胞和艾氏癌瘤细胞的小鼠中研究了脱脂卡介苗热水提取物的抗肿瘤活性。发现该热水提取物在接种肿瘤细胞后给药有效，而在接种肿瘤细胞前给药无效。当将该提取物与丝裂霉素C和环磷酰胺等抗癌药物联合使用时，在治疗肉瘤-180和艾氏癌瘤方面可获得协同效应。
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