School of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu Province, China.
School of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu Province, China.
J Colloid Interface Sci. 2022 Dec;627:194-204. doi: 10.1016/j.jcis.2022.06.178. Epub 2022 Jul 4.
The emerging aqueous-based Cerberus emulsion droplets with multi-domains behave as an excellent platform to design cyto-mimetic compartmentalization for fabrication of anisotropic biomimetic materials and microreactors. However, the ultralow water/water interfacial tension impedes fabrication of aqueous Cerberus droplets in batch-scale and precisely topology regulation especially under lack of deep understanding of w/w interface properties.
Aqueous-based ternary phase diagram composed by salt, hydrophilic polymer and fluorocarbon compound is determined. Different emulsions employing the multiple aqueous solutions as internal phase and vegetable oil as continuous phase, are prepared by traditional vortex mixing based on the diagram. The construction mechanism of (W1 + W2 + W3)/O Cerberus droplets and relationship between droplet topology and the diagram are investigated.
Diverse categories of aqueous-based emulsions from single emulsions, Janus emulsions, to Cerberus emulsions are delicately controlled in the same system based on the diagram. Various morphologies of Cerberus droplets such as linear and fan-like configurations are obtained, although spreading coefficient based on interfacial tension indicates preference of onion-like configuration. The viscosity plays an unexpected role in the construction of Cerberus droplets due to highly sensitive water/water interfaces within the droplets. Moreover, an empirical equation is perfectly applied, which endows quantitative prediction and control of lobe volume ratio within Cerberus droplets.
新兴的水基 Cerberus 乳液滴具有多域结构，可作为设计细胞模拟隔间的优秀平台，用于制造各向异性仿生材料和微反应器。然而，超低的水/水界面张力阻碍了批量生产水基 Cerberus 乳液滴的能力，特别是在缺乏对 w/w 界面性质深入了解的情况下，难以精确调控乳液滴的拓扑结构。
确定了由盐、亲水性聚合物和氟碳化合物组成的水基三元相图。根据相图，采用多种水溶液作为内相，植物油作为连续相，通过传统的涡旋混合制备不同的乳液。研究了（W1+W2+W3）/O Cerberus 乳液滴的构建机制以及乳液滴拓扑结构与相图之间的关系。
根据相图，在同一体系中可以精细调控各种水基乳液，包括单相乳液、Janus 乳液和 Cerberus 乳液。尽管基于界面张力的铺展系数表明洋葱状结构更具优势，但可以获得 Cerberus 乳液滴的各种形态，如线性和扇形结构。由于乳液滴内的水/水界面高度敏感，粘度在 Cerberus 乳液滴的构建中起着意想不到的作用。此外，还可以完美应用经验方程，对 Cerberus 乳液滴中叶瓣体积比进行定量预测和控制。
