Uenami A, Mizuno T, Chiba H, Ohno M, Wakino K, Sawada Y, Ohno J, Kume K
J Cardiogr. 1986 Jun;16(2):301-8.
Serial radionuclide ventriculography was performed using a newly developed "real-time" system, and left ventricular ejection fraction (LVEF), right ventricular ejection fraction (RVEF), stroke volume (SV), and cardiac output (CO) were measured during graded supine exercise in five patients with mitral stenosis (MS), in five patients with chronic obstructive pulmonary disease (COPD) and in five healthy subjects. Simultaneous pulmonary gas exchange analysis permitted determining the anaerobic threshold, which is the point during incremental exercise when lactate begins to accumulate in the blood. LVEF at the anaerobic threshold was not significantly changed in any patient groups and in healthy subjects, but RVEF at the anaerobic threshold was lower in COPD and MS patients as compared with healthy subjects. In MS, SV during exercise was reduced at the anaerobic threshold, but not in COPD or in healthy subjects. In conclusion, reduced working capacity is related to decreased RVEF in both COPD and MS, but the inhibited increase in CO during exercise is also important for the working capacity in MS.
采用新开发的“实时”系统进行系列放射性核素心室造影，在5例二尖瓣狭窄（MS）患者、5例慢性阻塞性肺疾病（COPD）患者和5名健康受试者进行分级仰卧运动期间，测量左心室射血分数（LVEF）、右心室射血分数（RVEF）、每搏输出量（SV）和心输出量（CO）。同时进行肺气体交换分析以确定无氧阈值，无氧阈值是递增运动期间血液中乳酸开始积累的时间点。在任何患者组和健康受试者中，无氧阈值时的LVEF均无显著变化，但与健康受试者相比，COPD和MS患者无氧阈值时的RVEF较低。在MS中，运动期间无氧阈值时的SV降低，但在COPD患者或健康受试者中未降低。总之，工作能力下降与COPD和MS患者的RVEF降低有关，但运动期间CO增加受抑制对MS患者的工作能力也很重要。
