Amano N, Ochiai K, Tohtake T, Terashima Y, Kato J
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Apr;39(4):670-4.
Tamoxifen is a nonsteroidal antiestrogen whose mode of action is, as yet, unclear. The purpose of this report is to investigate the effects of Tamoxifen on endometrial adenocarcinoma ultrastructurally. Five patients with endometrial adenocarcinoma, 3 cases well differentiated and the others undifferentiated, were treated with 20mg Tamoxifen per os a day for 7 days, and the following changes were observed: The cells became roundish and slightly swollen. Development of cytoplasmic organelles was observed. In the cytoplasm, glycogen granules did not increase. These results suggest that an anti-cancer effect is brought about by the induction of the tissue toward functional differentiation as well as inhibition of glycogen metabolism in tumor cells.
他莫昔芬是一种非甾体类抗雌激素药物，其作用机制尚不清楚。本报告的目的是从超微结构方面研究他莫昔芬对子宫内膜腺癌的影响。5例子宫内膜腺癌患者，3例高分化，其余未分化，每天口服20mg他莫昔芬，共7天，观察到以下变化：细胞变为圆形且略有肿胀。观察到细胞质细胞器的发育。细胞质中糖原颗粒没有增加。这些结果表明，通过诱导组织向功能分化以及抑制肿瘤细胞中的糖原代谢可产生抗癌作用。
