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艾氯胺酮——一种速效新型抗抑郁药,无氯胺酮的缺点。

Esketamine-A quick-acting novel antidepressant without the disadvantages of ketamine.

作者信息

Shoib Sheikh, Kotra Madhulika, Javed Sana, Nguyen Vinh-Son, Malathesh Barikar C

机构信息

Department of Psychiatry, Jawahar Lal Nehru Memorial Hospital, Srinagar, Kashmir, India.

M S Ramaiah Medical College, Bangalore, India.

出版信息

Horm Mol Biol Clin Investig. 2022 Jul 15;43(4):505-511. doi: 10.1515/hmbci-2021-0099. eCollection 2022 Dec 1.

DOI:10.1515/hmbci-2021-0099
PMID:35851448
Abstract

Esketamine, which is an S-enantiomer of ketamine, is better than conventional antidepressants and even better than R-ketamine. This article discusses the mechanism of action of Esketamine, how different it is from other antidepressants, its side effect profile, indications for use, various routes of administration and the review of existing literature on Esketamine.

摘要

艾氯胺酮是氯胺酮的S-对映体,它比传统抗抑郁药效果更好,甚至优于R-氯胺酮。本文讨论了艾氯胺酮的作用机制、与其他抗抑郁药的差异、副作用、使用指征、各种给药途径以及关于艾氯胺酮的现有文献综述。

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Esketamine-A quick-acting novel antidepressant without the disadvantages of ketamine.艾氯胺酮——一种速效新型抗抑郁药,无氯胺酮的缺点。
Horm Mol Biol Clin Investig. 2022 Jul 15;43(4):505-511. doi: 10.1515/hmbci-2021-0099. eCollection 2022 Dec 1.
2
Pharmacotherapy: Ketamine and Esketamine.药物治疗:氯胺酮和艾司氯胺酮。
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Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1).依他佐辛鼻喷剂固定剂量联合新型抗抑郁药治疗难治性抑郁症的疗效和安全性:一项随机、双盲、阳性对照研究(TRANSFORM-1)的结果。
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Relapse prevention in treatment-resistant major depressive disorder with rapid-acting antidepressants.使用速效抗抑郁药预防难治性重度抑郁症的复发
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Differential effectiveness between Ketamine and Esketamine: the predictive role of dissociative features. A treatment-resistant depression case.氯胺酮与艾司氯胺酮的疗效差异:分离特质的预测作用。一个治疗抵抗性抑郁症的案例。
Int Clin Psychopharmacol. 2024 Mar 1;39(2):117-119. doi: 10.1097/YIC.0000000000000497. Epub 2023 Jul 7.
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Long-term safety of ketamine and esketamine in treatment of depression.氯胺酮和艾司氯胺酮治疗抑郁症的长期安全性。
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Arketamine, a new rapid-acting antidepressant: A historical review and future directions.氯胺酮,一种新型快速抗抑郁药:历史回顾与未来方向。
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Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study.灵活剂量依他佐辛鼻喷雾剂联合新起始口服抗抑郁药治疗难治性抑郁症的疗效和安全性:一项随机、双盲、活性对照研究。
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Intranasal esketamine: A novel drug for treatment-resistant depression.鼻内依他佐辛:一种用于治疗抵抗性抑郁症的新型药物。
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Rethinking ketamine and esketamine action: Are they antidepressants with mood-stabilizing properties?重新思考氯胺酮和 Esketamine 的作用:它们是具有稳定情绪作用的抗抑郁药吗?
Eur Neuropsychopharmacol. 2023 May;70:49-55. doi: 10.1016/j.euroneuro.2023.02.010. Epub 2023 Mar 1.

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Effects of Esketamine Versus Remifentanil on Hemodynamics and Prognosis in Patients with Septic Shock Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial.艾司氯胺酮与瑞芬太尼对接受有创机械通气的感染性休克患者血流动力学及预后的影响:一项随机对照试验
Drug Des Devel Ther. 2025 May 21;19:4139-4149. doi: 10.2147/DDDT.S520252. eCollection 2025.
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Effects of esketamine-sufentanil for patient-controlled intravenous analgesia in women following cesarean section: A randomized clinical trial.艾司氯胺酮-舒芬太尼用于剖宫产术后女性患者自控静脉镇痛的效果:一项随机临床试验
Front Pharmacol. 2025 Apr 14;16:1579633. doi: 10.3389/fphar.2025.1579633. eCollection 2025.
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The efficacy and safety of patient-controlled intravenous analgesia with esketamine after total hip arthroplasty: a randomized controlled trial.
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BMC Anesthesiol. 2025 Jan 20;25(1):31. doi: 10.1186/s12871-025-02894-6.
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Efficacy and safety of perioperative application of esketamine on postoperative depression: a meta-analysis of randomized controlled studies.艾司氯胺酮围手术期应用对术后抑郁的疗效及安全性:一项随机对照研究的荟萃分析
Int J Surg. 2025 Jan 1;111(1):1191-1202. doi: 10.1097/JS9.0000000000001870.
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Esketamine combined with sufentanil sufentanil in patient-controlled intravenous analgesia: a meta-analysis.艾司氯胺酮联合舒芬太尼用于患者自控静脉镇痛的荟萃分析
Front Pharmacol. 2024 Feb 7;15:1247646. doi: 10.3389/fphar.2024.1247646. eCollection 2024.
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Effect of intravenous induction with different doses of Esketamine combined with propofol and sufentanil on intraocular pressure among pediatric strabismus surgery: a randomized clinical trial.不同剂量依托咪酯复合舒芬太尼联合氯胺酮静脉诱导对小儿斜视手术眼内压的影响:一项随机临床试验。
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