Santiago Camilla M O, de Oliveira Dalila G, Rocha-Gomes Arthur, Oliveira Gabriel A, Bernardes Eduardo de Oliveira, Dias Patrick L, Reis Ítalo G, Severiano Cecília M, da Silva Alexandre A, Lessa Mayara R, Dessimoni Pinto Nisia A V, Riul Tania R
Programa de Pós-Graduação em Ciências da Nutrição, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil.
Laboratório de Nutrição Experimental, LabNutrex, Departamento de Nutrição, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil.
J Food Biochem. 2022 Oct;46(10):e14341. doi: 10.1111/jfbc.14341. Epub 2022 Jul 19.
The present study aimed to evaluate the nutritional and redox status of supplementation with unripe banana flour (Musa cavendishii) in high-fat-fed Wistar rats. Male Wistar rats were divided into the following groups for 98 days: control-lab chow; unripe banana flour (UBF)-lab chow with added unripe banana flour; high-fat (HFD)-lab chow with added lard; unripe banana flour + high-fat (UBF + HFD)-lab chow with added unripe banana flour and lard. The HFD group showed higher caloric intake, weight gain, abdominal fat accumulation, steatosis, and oxidative stress in the hypothalamus than the other groups. Conversely, the HFD + UBF group showed reduced caloric intake, weight gain, and abdominal adipose tissue accumulation compared to the HFD group. Notably, an improvement in the redox state of the hypothalamus was observed in the HFD + UBF group. However, this group showed a worsening redox state and fat accumulation in the liver. PRACTICAL APPLICATIONS: The prevalence of obesity has increased worldwide over the past 50 years, reaching pandemic levels. It is also possible that, although it is a multifactorial disease, the main cause of obesity development is still related to a high intake of high-fat diets. Therefore, it is imperative to establish alternatives for the control and treatment of obesity. Here, we showed that unripe banana flour can improve hypothalamic antioxidant activity, reduce caloric intake, and prevent abdominal fat accumulation. These outcomes indicate the anti-obesity potential of unripe banana flour and highlight the need for future studies. However, the damage observed in the liver indicated that, at the concentrations used in the present study, its use should be carefully evaluated.
本研究旨在评估在高脂喂养的Wistar大鼠中补充未成熟香蕉粉（卡文迪什香蕉）后的营养和氧化还原状态。雄性Wistar大鼠被分为以下几组，为期98天：对照组—实验室标准饲料；未成熟香蕉粉（UBF）组—添加未成熟香蕉粉的实验室标准饲料；高脂（HFD）组—添加猪油的实验室标准饲料；未成熟香蕉粉+高脂（UBF + HFD）组—添加未成熟香蕉粉和猪油的实验室标准饲料。与其他组相比，HFD组的热量摄入、体重增加、腹部脂肪堆积、脂肪变性和下丘脑氧化应激更高。相反，与HFD组相比，HFD + UBF组的热量摄入、体重增加和腹部脂肪组织堆积减少。值得注意的是，在HFD + UBF组中观察到下丘脑氧化还原状态有所改善。然而，该组肝脏的氧化还原状态恶化且脂肪堆积增加。实际应用：在过去50年里，肥胖症在全球的患病率有所上升，已达到大流行水平。尽管肥胖是一种多因素疾病，但肥胖发展的主要原因仍可能与高脂肪饮食的高摄入量有关。因此，必须建立控制和治疗肥胖症的替代方法。在此，我们表明未成熟香蕉粉可以提高下丘脑抗氧化活性，减少热量摄入，并防止腹部脂肪堆积。这些结果表明未成熟香蕉粉具有抗肥胖潜力，并突出了未来研究的必要性。然而，在肝脏中观察到的损伤表明，在本研究使用的浓度下，其使用应谨慎评估。
